Journal of Diabetes and Its Complications
Volume 25, Issue 3 , Pages 175-182 , May 2011

Depression and incident lower limb amputations in veterans with diabetes

  • Lisa H. Williams

      Affiliations

    • VA Health Services Research & Development Center of Excellence, Seattle, WA, USA
    • Dermatology, University of Washington School of Medicine, Seattle, WA, USA
    • Corresponding Author InformationCorresponding author. Group Health Cooperative, 125 16th Ave E, CSB-5, Seattle, WA 98112, USA.
    • ,
  • Donald R. Miller

      Affiliations

    • VA Center for Health Quality, Outcomes, and Economic Research, Bedford, MA, USA
    • Health Policy and Management, Boston University School of Public Health, Boston, MA, USA
    • ,
  • Graeme Fincke

      Affiliations

    • VA Center for Health Quality, Outcomes, and Economic Research, Bedford, MA, USA
    • Health Policy and Management, Boston University School of Public Health, Boston, MA, USA
    • ,
  • Jean-Philippe Lafrance

      Affiliations

    • VA Center for Health Quality, Outcomes, and Economic Research, Bedford, MA, USA
    • Health Policy and Management, Boston University School of Public Health, Boston, MA, USA
    • ,
  • Ruth Etzioni

      Affiliations

    • Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    • ,
  • Charles Maynard

      Affiliations

    • VA Health Services Research & Development Center of Excellence, Seattle, WA, USA
    • Health Services, University of Washington School of Public Health, Seattle, WA, USA
    • ,
  • Gregory J. Raugi

      Affiliations

    • VA Health Services Research & Development Center of Excellence, Seattle, WA, USA
    • Dermatology, University of Washington School of Medicine, Seattle, WA, USA
    • ,
  • Gayle E. Reiber

      Affiliations

    • VA Health Services Research & Development Center of Excellence, Seattle, WA, USA
    • Health Services and Epidemiology, University of Washington School of Public Health, Seattle, WA, USA

Received 4 September 2009 ,Revised 29 June 2010 ,Accepted 13 July 2010.

References 

  1. Adler AI, Boyko EJ, Ahroni JH, Smith DG. Lower-extremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers. Diabetes Care. 1999;22:1029–1035
  2. Ali S, Stone MA, Peters JL, Davies MJ, Khunti K. The prevalence of co-morbid depression in adults with type 2 diabetes: A systematic review and meta-analysis. Diabetic Medicine. 2006;23:1165–1173
  3. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: A meta-analysis. Diabetes Care. 2001;24:1069–1078
  4. Armstrong DG, Lavery LA, Kimbriel HR, Nixon BP, Boulton AJ. Activity patterns of patients with diabetic foot ulceration: Patients with active ulceration may not adhere to a standard pressure off-loading regimen. Diabetes Care. 2003;26:2595–2597
  5. Black SA, Markides KS, Ray LA. Depression predicts increased incidence of adverse health outcomes in older Mexican Americans with type 2 diabetes. Diabetes Care. 2003;26:2822–2828
  6. Bosch JA, Engeland CG, Cacioppo JT, Marucha PT. Depressive symptoms predict mucosal wound healing. Psychosomatic Medicine. 2007;69:597–605
  7. Brunner EJ, Hemingway H, Walker BR, Page M, Clarke P, Juneja M, et al. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: Nested case-control study. Circulation. 2002;106:2659–2665
  8. Carrington AL, Mawdsley SK, Morley M, Kincey J, Boulton AJ. Psychological status of diabetic people with or without lower limb disability. Diabetes Research and Clinical Practice. 1996;32:19–25
  9. Cherr GS, Wang J, Zimmerman PM, Dosluoglu HH. Depression is associated with worse patency and recurrent leg symptoms after lower extremity revascularization. Journal of Vascular Surgery. 2007;45:744–750
  10. Ciechanowski P, Russo J, Katon W, Simon G, Ludman E, Von Korff M, et al. Where is the patient? The association of psychosocial factors and missed primary care appointments in patients with diabetes. General Hospital Psychiatry. 2006;28:9–17
  11. Cole-King A, Harding KG. Psychological factors and delayed healing in chronic wounds. Psychosomatic Medicine. 2001;63:216–220
  12. D'Agostino RB, Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM, et al. General cardiovascular risk profile for use in primary care: The Framingham heart study. Circulation. 2008;117:743–753
  13. de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ. Association of depression and diabetes complications: A meta-analysis. Psychosomatic Medicine. 2001;63:619–630
  14. Ell K, Katon W, Xie B, Lee PJ, Kapetanovic S, Guterman J, et al. Collaborative care management of major depression among low-income, predominantly Hispanic subjects with diabetes: a randomized controlled trial. Diabetes Care. 2010;33:706–713
  15. Fox-Wasylyshyn SM, El-Masri MM. Handling missing data in self-report measures. Research in Nursing & Health. 2005;28:488–495
  16. Golden SH, Lazo M, Carnethon M, Bertoni AG, Schreiner PJ, Roux AV, et al. Examining a bidirectional association between depressive symptoms and diabetes. Journal of the American Medical Association. 2008;299:2751–2759
  17. Ismail K, Winkley K, Stahl D, Chalder T, Edmonds M. A cohort study of people with diabetes and their first foot ulcer: The role of depression on mortality. Diabetes Care. 2007;30:1473–1479
  18. Johnston MV, Pogach L, Rajan M, Mitchinson A, Krein SL, Bonacker K, et al. Personal and treatment factors associated with foot self-care among veterans with diabetes. Journal of Rehabilitation Research and Development. 2006;43:227–238
  19. Joynt KE, Whellan DJ, O'Connor CM. Depression and cardiovascular disease: Mechanisms of interaction. Biological Psychiatry. 2003;54:248–261
  20. Katon W, Fan MY, Unutzer J, Taylor J, Pincus H, Schoenbaum M. Depression and diabetes: A potentially lethal combination. Journal of General Internal Medicine. 2008;23:1571–1575
  21. Katon W, Lin EH, Von Korff M, Ciechanowski P, Ludman E, Young B, et al. Integrating depression and chronic disease care among patients with diabetes and/or coronary heart disease: The design of the TEAMcare study. Contemp Clin Trials. 2010;[Epub ahead of print]
  22. Katon WJ, Russo JE, Von Korff M, Lin EH, Ludman E, Ciechanowski PS. Long-term effects on medical costs of improving depression outcomes in patients with depression and diabetes. Diabetes Care. 2008;31:1155–1159
  23. Katon WJ, Rutter C, Simon G, Lin EH, Ludman E, Ciechanowski P, et al. The association of comorbid depression with mortality in patients with type 2 diabetes. Diabetes Care. 2005;28:2668–2672
  24. Kiank C, Daeschlein G, Schuett C. Pneumonia as a long-term consequence of chronic psychological stress in balb/c mice. Brain, Behavior, and Immunity. 2008;
  25. Kiank C, Entleutner M, Furll B, Westerholt A, Heidecke CD, Schutt C. Stress-induced immune conditioning affects the course of experimental peritonitis. Shock. 2007;27:305–311
  26. Lin EH, Katon W, Von Korff M, Rutter C, Simon GE, Oliver M, et al. Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care. 2004;27:2154–2160
  27. Liu CF, Campbell DG, Chaney EF, Li YF, McDonell M, Fihn SD. Depression diagnosis and antidepressant treatment among depressed VA primary care patients. Administration and Policy in Mental Health. 2006;33:331–341
  28. Mayfield JA, Reiber GE, Maynard C, Czerniecki J, Sangeorzan B. The epidemiology of lower-extremity disease in veterans with diabetes. Diabetes Care. 2004;27(Suppl 2):B39–B44
  29. Miller DR, Safford MM, Pogach LM. Who has diabetes? Best estimates of diabetes prevalence in the department of veterans affairs based on computerized patient data. Diabetes Care. 2004;27(Suppl. 2):B10–B21
  30. Monami M, Longo R, Desideri CM, Masotti G, Marchionni N, Mannucci E. The diabetic person beyond a foot ulcer: Healing, recurrence, and depressive symptoms. Journal of American Podiatric Medical Association. 2008;98:130–136
  31. Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care. 1990;13:513–521
  32. Raikkonen K, Matthews KA, Kuller LH. Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women: A comparison of world health organization, adult treatment panel iii, and international diabetes foundation definitions. Diabetes Care. 2007;30:872–877
  33. Reiber GE, Pecoraro RE, Koepsell TD. Risk factors for amputation in patients with diabetes mellitus. A case-control study. Annals of Internal Medicine. 1992;117:97–105
  34. Reiber GE, Raugi GJ, Rowberg D. The process of implementing a rural VA wound care program for diabetic foot ulcer patients. Ostomy/Wound Management. 2007;53:60–66
  35. Rojas IG, Padgett DA, Sheridan JF, Marucha PT. Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain, Behavior, and Immunity. 2002;16:74–84
  36. Roy MS, Affouf M, Roy A. Six-year incidence of proteinuria in Type 1 diabetic African Americans. Diabetes Care. 2007;30:1807–1812
  37. Roy MS, Roy A, Affouf M. Depression is a risk factor for poor glycemic control and retinopathy in African-Americans with type 1 diabetes. Psychosomatic Medicine. 2007;69:537–542
  38. Selby JV, Zhang D. Risk factors for lower extremity amputation in persons with diabetes. Diabetes Care. 1995;18:509–516
  39. Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, et al. Vascular risk factors and diabetic neuropathy. The New England Journal of Medicine. 2005;352:341–350
  40. Tseng CL, Greenberg JD, Helmer D, Rajan M, Tiwari A, Miller D, et al. Dual-system utilization affects regional variation in prevention quality indicators: The case of amputations among veterans with diabetes. The American Journal of Managed Care. 2004;10:886–892
  41. Tseng CL, Sambamoorthi U, Helmer D, Tiwari A, Rosen AK, Rajan M, et al. The association between mental health functioning and nontraumatic lower extremity amputations in veterans with diabetes. General Hospital Psychiatry. 2007;29:537–546
  42. Valenstein M, Taylor KK, Austin K, Kales HC, McCarthy JF, Blow FC. Benzodiazepine use among depressed patients treated in mental health settings. The American Journal of Psychiatry. 2004;161:654–661
  43. Vileikyte L, Leventhal H, Gonzalez JS, Peyrot M, Rubin RR, Ulbrecht JS, et al. Diabetic peripheral neuropathy and depressive symptoms: The association revisited. Diabetes Care. 2005;28:2378–2383
  44. Wattanakit K, Williams JE, Schreiner PJ, Hirsch AT, Folsom AR. Association of anger proneness, depression and low social support with peripheral arterial disease: The atherosclerosis risk in communities study. Vascular Medicine. 2005;10:199–206
  45. Willrich A, Pinzur M, McNeil M, Juknelis D, Lavery L. Health related quality of life, cognitive function, and depression in diabetic patients with foot ulcer or amputation. A preliminary study. Foot & Ankle International. 2005;26:128–134
  46. Winkley K, Stahl D, Chalder T, Edmonds ME, Ismail K. Risk factors associated with adverse outcomes in a population-based prospective cohort study of people with their first diabetic foot ulcer. Journal of Diabetes and its Complications. 2007;21:341–349
  47. Wrobel JS, Mayfield JA, Reiber GE. Geographic variation of lower-extremity major amputation in individuals with and without diabetes in the Medicare population. Diabetes Care. 2001;24:860–864

☆ Disclosure. Dr. Miller has received grant funding from Sanofi Aventis, GlaxoSmithKline, and Merck within the last three years. The remaining authors have no relevant conflicts of interest to disclose.

☆☆ Parts of this study were presented at the 5th International Dermato-Epidemiology Association Congress in Nottingham, England, on 9/8/08, and at the 2009 Annual Health Services Research and Development National Meeting in Baltimore, Maryland, on 2/11/09. An abstract from this study was published in Williams LH, Miller DR, Raugi GJ, Etzioni R, Maynard C, Reiber GE. Depression and incident lower limb amputation in veterans with diabetes. Journal of Investigative Dermatology 2008 128:2553. Abstract 24.

PII: S1056-8727(10)00073-5

doi: 10.1016/j.jdiacomp.2010.07.002

Journal of Diabetes and Its Complications
Volume 25, Issue 3 , Pages 175-182 , May 2011

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