Journal of Diabetes and Its Complications
Volume 25, Issue 2 , Pages 137-141 , March 2011

Diabetic keto-acidosis as a presentation of cystic fibrosis-related diabetes: a case report

  • Vera Eenkhoorn

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Annelies Van den Driessche

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Luc Van Gaal

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Kristine Desager

      Affiliations

    • Department of Pediatrics, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Christophe De Block

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • Corresponding Author InformationCorresponding author. Department of Endocrinology, Diabetology and Metabolic Diseases, Faculty of Medicine, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium. Tel.: +3238213275; fax: +3238254980.

Received 26 January 2010 ,Revised 6 May 2010 ,Accepted 28 May 2010.

References 

  1. Alves C, Aguiar R, Alves AC, Santana MA. Diabetes mellitus in patients with cystic fibrosis. Jornal Brasileiro de Pneumologia. 2007;33:213–221
  2. Brennan AL, Geddes DM, Gyi KM, Baker EH. Clinical importance of cystic fibrosis-related diabetes. Journal of Cystic Fibrosis. 2004;3:209–222
  3. Costa M, Potvin S, Berthiaume Y, et al. Diabetes: a major co-morbidity of cystic fibrosis. Diabetes & Metabolism. 2005;31:221–232
  4. Debacker N, Krzentowski G, Mathieu C, et al. Initiatief voor Kwaliteitsbevordering en Epidemiologie bij Diabetes. http://www.iph.fgov.be/reports.asp2007;
  5. Dobson L, Sheldon CD, Hattersley AT. Understanding cystic-fibrosis-related diabetes: best thought of as insulin deficiency?. Journal of the Royal Society of Medicine. 2004;97(Suppl. 44):26–35
  6. Hardin DS, Leblanc A, Marshall G, Seilheimer DK. Mechanisms of insulin resistance in cystic fibrosis. American Journal of Physiology Endocrinology Metabolism. 2001;281:E1022–E1028
  7. Hardin DS, Leblanc A, Para L, Seilheimer DK. Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis. Diabetes. 1999;48:1082–1087
  8. Lanng S, Thorsteinsson B, Nerup J, Koch C. Diabetes mellitus in cystic fibrosis: a ten-year prospective study. Diabetologia. 2000;43:107A
  9. Mackie ADR, Thornton SJ, Edenborough FP. Cystic fibrosis-related diabetes. Diabetic Medicine. 2003;20:425–436
  10. Mahroukh R, Chapman K, Stewart C, et al. Changes in response to insulin and the effect of varying glucose tolerance on whole-body protein metabolism in patients with cystic fibrosis. American Journal of Clinical Nutrition. 2005;81:421–426
  11. Minicucci L, Cotellessa M, Pittaluga L, et al. Beta-cell autoantibodies and diabetes mellitus family history in cystic fibrosis. Journal of Pediatric Endocrinology & Metabolism. 2005;18:755–760
  12. Mohan K, Miller H, Burhan H, Ledson MJ, Walshaw MJ. Management of cystic fibrosis related diabetes: a survey of UK cystic fibrosis centres. Pediatric Pulmonology. 2008;43:642–647
  13. Moran A. Cystic fibrosis-related diabetes: an approach to diagnosis and management. Pediatric Diabetes. 2000;1:41–48
  14. Moran A, Hardin D, Rodman D, et al. Diagnosis, screening and management of cystic fibrosis related diabetes mellitus. A consensus conference report. Diabetes Research and Clinical Practice. 1999;45:61–73
  15. Preumont V, Lebecque P, Hermans MP, Buysschaert M. Glucose homeostasis and genotype–phenotype interplay in cystic fibrosis patients with CFTR gene delta F 508 mutation. Diabetes Care. 2008;30:1187–1192
  16. Saag KG, Furst DE. Major side effects of systemic glucocorticoids. http://www.utdol.com2010;
  17. Schwarzenberg SJ, Walk D, Thomas W, et al. Microvascular complications in cystic fibrosis-related diabetes. Diabetes Care. 2007;30:1056–1061
  18. Stechova K, Kolouskova S, Sumnik Z, et al. Anti-GAD65 reactive peripheral blood mononuclear cells in the pathogenesis of cystic fibrosis related diabetes mellitus. Autoimmunity. 2005;38:319–323

☆ Declaration of interest: there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

☆☆ Funding: This paper did not receive any specific grant from any funding agency in the public, commercial, or non-for-profit sector.

PII: S1056-8727(10)00065-6

doi: 10.1016/j.jdiacomp.2010.05.003

Journal of Diabetes and Its Complications
Volume 25, Issue 2 , Pages 137-141 , March 2011

Article Tools