Journal of Diabetes and Its Complications
Volume 25, Issue 2 , Pages 137-141, March 2011

Diabetic keto-acidosis as a presentation of cystic fibrosis-related diabetes: a case report☆☆☆

  • Vera Eenkhoorn

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Annelies Van den Driessche

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Luc Van Gaal

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Kristine Desager

      Affiliations

    • Department of Pediatrics, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • ,
  • Christophe De Block

      Affiliations

    • Department of Endocrinology, Diabetology and Metabolic Diseases, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
    • Corresponding Author InformationCorresponding author. Department of Endocrinology, Diabetology and Metabolic Diseases, Faculty of Medicine, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium. Tel.: +3238213275; fax: +3238254980.

Received 26 January 2010; received in revised form 6 May 2010; accepted 28 May 2010. published online 26 July 2010.

Abstract 

Cystic fibrosis (CF) is one of the most common genetically inherited diseases and often complicated by diabetes mellitus. With increasing longevity, the incidence and prevalence of cystic fibrosis-related diabetes (CFRD) rise and microvascular complications develop. CFRD is an entity on its own with characteristics seen in both type 1 and type 2 diabetes. Keto-acidosis, a potentially life-threatening complication of diabetes, is an extremely rare presentation of CFRD.

Here we present the history of a 21-year-old CF patient with no prior diagnosis of CFRD who developed keto-acidosis after an episode of pulmonary infection.

Based on this case report we would like to emphasize the importance of screening for and early treatment of CFRD. We also discuss the management policy of CFRD and when and whether to initiate insulin therapy.

Keywords: Diabetic keto-acidosis, Cystic fibrosis-related diabetes, Pulmonary infection

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☆ Declaration of interest: there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

☆☆ Funding: This paper did not receive any specific grant from any funding agency in the public, commercial, or non-for-profit sector.

PII: S1056-8727(10)00065-6

doi:10.1016/j.jdiacomp.2010.05.003

Journal of Diabetes and Its Complications
Volume 25, Issue 2 , Pages 137-141, March 2011

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