Journal of Diabetes and Its Complications
Volume 25, Issue 2 , Pages 73-82 , March 2011

LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses

  • Richard L. Klein

      Affiliations

    • Division of Endocrinology, Metabolism, and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    • Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
    • Corresponding Author InformationCorresponding author. Medical University of South Carolina, 114 Doughty Street, STB 501, Charleston, SC 29403, USA. Tel.: +1 843 789 6801; fax: +1 843 876 5133.
    • ,
  • Rickey E. Carter

      Affiliations

    • Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Alicia J. Jenkins

      Affiliations

    • Division of Endocrinology, Metabolism, and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    • Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Australia
    • Section of Endocrinology and Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    • ,
  • Timothy J. Lyons

      Affiliations

    • Section of Endocrinology and Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    • ,
  • Nathaniel L. Baker

      Affiliations

    • Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Gregory E. Gilbert

      Affiliations

    • Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Gabriel Virella

      Affiliations

    • Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Maria F. Lopes-Virella

      Affiliations

    • Division of Endocrinology, Metabolism, and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    • Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
    • ,
  • the DCCT/EDIC Research Group

      Affiliations

    • Box NDIC/DCCT, Bethesda, MD

Received 11 January 2010 ,Revised 15 March 2010 ,Accepted 29 March 2010.

References 

  1. Baynes JW. Glycoxidation and lipoxidation in atherogenesis. Free Radical Biology & Medicine. 2000;28:1708–1716
  2. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 1999;48:1–9
  3. Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group. Intensive diabetes therapy and carotid intima-media thickness in Type 1 diabetes mellitus. The New England Journal of Medicine. 2003;348:2294–2303
  4. Epidemiology of Diabetes Interventions and Complications (EDIC) Study Group. Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort. Diabetes Care. 1999;22:99–111
  5. Jenkins AJ, Best JD, Klein RL, Lyons TJ. Lipoproteins, glycoxidation, and diabetic angiopathy. Diabet Metab Res Rev. 2004;20:349–368
  6. Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland D, McGee D, et al. Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort. J Investig Opthamol Vis Sci. 2004;45:910–918
  7. Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland DT, McGee D, et al. Serum lipoproteins in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications cohort: Associations with gender and glycemia. Diabetes Care. 2003;26:810–818
  8. Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland DT, McGee D, et al. Lipoproteins in the DCCT/EDIC cohort: Associations with diabetic nephropathy. Kidney International. 2003;64:817–828
  9. Jenkins AJ, Rowley KG, Lyons TJ, Best JD, Hill MJ, Klein RL. Lipoproteins and diabetic microvascular complications. Current Pharmaceutical Design. 2004;10:3395–3418
  10. Klein RL, McHenry MB, Lok KH, Hunter SJ, Le NA, Jenkins AJ, et al. Apolipoprotein C-III protein concentration and gene polymorphisms in type 1 diabetes: Associations with lipoprotein subclasses. Metabolism. 2004;53:1295–1303
  11. Kramer CY. Extension of multiple range tests to group means with unequal numbers of replications. Biometrics. 1956;12:307–310
  12. Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, et al. Multiple immuno-regulatory defects in type-1 diabetes. The Journal of Clinical Investigation. 2002;109:131–140
  13. Lockwood CM, MacKinnon DP. Bootstrapping the standard error of the mediated effect. In: Paper presented at the 23rd Annual Meeting of SAS Users Group International, Cary, NC. 1998;
  14. Lopes-Virella MF, Binzafar N, Rackley S, Takei A, La Via M, Virella G. The uptake of LDL‑IC by human macrophages: Predominant involvement of the Fcγ-RI receptor. Atherosclerosis. 1997;135:161–170
  15. Lopes-Virella MF, Klein RL, Virella G. Modification of lipoproteins in diabetes. Diabet Metab Res Rev. 1996;12:69–90
  16. Lopes-Virella MF, McHenry MB, Lipsitz S, Yim E, Wilson PF, Lackland DT, et al. Immune complexes containing modified lipoproteins are related to the progression of internal carotid intima-media thickness in patients with type 1 diabetes. Atherosclerosis. 2007;190:359–369
  17. Lopes-Virella MF, Virella G. The role of immune and inflammatory processes in the development of macrovascular disease in diabetes. Frontiers in Bioscience. 2003;8:s750–768
  18. Lopes-Virella MF, Virella G, Orchard TJ, Koskinen S, Evans RW, Becker DJ, et al. Antibodies to oxidized LDL and LDL-containing immune complexes as risk factors for coronary artery disease in diabetes mellitus. Clinical Immunology. 1999;90:165–172
  19. Lyons TJ, Jenkins AJ, Zheng D, Klein RL, Otvos JD, Yu Y, et al. Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness. Diabetic Medicine. 2006;23:955–966
  20. MacKinnon D, Lockwood CM, Hoffman JM, West SG, Sheets V. A comparison of methods to test mediation and other intervening variable effects. Psychological Methods. 2002;7:83–104
  21. Mironova M, Virella G, Virella-Lowell I, Lopes-Virella MF. Anti-modified LDL antibodies and LDL-containing immune complexes in IDDM patients and healthy controls. Clinical Immunology and Immunopathology. 1997;85:73–82
  22. Mora S, Szklo M, Otvos JD, Greenland P, Psaty BM, Goff DC, et al. LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2007;192:211–217
  23. Orchard TJ, Forrest KYZ, Becker DJ, Virella G, Lopes-Virella MF. Antibodies to oxidized LDL predict CAD in Type I diabetes: A nested case control study from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes. 1999;48:1454–1458
  24. Otvos JD. Measurement of lipoprotein subclass particles by NMR spectroscopy. Clinical Laboratory. 2002;48:171–180
  25. Saad AF, Virella G, Chassereau CN, Boackle RJ, Lopes-Virella MF. Autoimmune OxLDL immune-complexes activate the classical pathway of complement and induce cytokine production by Mono Mac 6 cells and primary human macrophages. Journal of Lipid Research. 2006;47:1975–1983
  26. Tukey, J.W. (1953). The problem of multiple comparisons. Unpublished report, Princeton University, Princeton, NJ.
  27. Virella G, Atchley DH, Koskinen S, Zheng D, Lopes-Virella MF. Proatherogenic and pro-inflammatory properties of immune complexes prepared with purified human oxLDL antibodies and human oxLDL. Clinical Immunology. 2002;105:81–92
  28. Virella G, Derrick MB, Pate V, Chassereau C, Thorpe SR, Lopes-Virella MF. Development of capture assays for different modifications of human low-density lipoprotein. Clinical and Diagnostic Laboratory Immunology. 2005;12:68–75
  29. Yla-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Atheroscler Thromb. 1994;14:32–40
  30. Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. The Journal of Clinical Investigation. 1989;84:1086–1095

☆ This research was supported by funding by the American Diabetes Association, Juvenile Diabetes Research Foundation (4-1998-272, 996001), National Institutes of Health (PO1 HL55782), The Diabetes Research and Wellness Foundation (Fairfax, VA, USA), and the Merit Review Program of the Department of Veterans Affairs. The DCCT/EDIC Research Group is sponsored through research contracts from the National Institute of Diabetes, Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institutes of Health.

PII: S1056-8727(10)00040-1

doi: 10.1016/j.jdiacomp.2010.03.001

Journal of Diabetes and Its Complications
Volume 25, Issue 2 , Pages 73-82 , March 2011

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