« Previous
Next »
Journal of Diabetes and Its Complications
Volume 24, Issue 6
, Pages 415-423
, November 2010
Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions
References
- . Role of NADPH oxidase in retinal vascular inflammation. Investigative Ophthalmology & Visual Science. 2008;49:3239–3244
- . NF-kappaB regulates phagocytic NAD(P)H oxidase by inducing the expression of gp91phox. The Journal of Biological Chemistry. 2006;281:5657–5667
- . Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney International. 2005;67:1890–1898
- . Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene. 2001;269:131–140
- . Effect of dietary vitamin E supplementation on vascular reactivity of the thoracic aorta in streptozotocin-diabetic rats. Pharmacology. 2001;62:56–64
- . Effect of the NAD(P)H oxidase inhibitor, apocynin, on peripheral nerve perfusion and function in diabetic rats. Life Sciences. 2003;73:1813–1824
- . Endothelial dysfunction in diabetes. British Journal of Pharmacology. 2000;130:963–974
- . NAD(P)H oxidase: role in cardiovascular biology and disease. Circulation Research. 2000;86:494–501
- . Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 1989;320:454–456
- . Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation. 2002;105:1656–1662
- . Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors. Circulation Research. 2000;86:E85–E90
- . NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension. 2002;40:755–762
- . NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction. Diabetes, Obesity & Metabolism. 2005;7:334–343
- . Apocynin is not an inhibitor of vascular NADPH oxidase but an antioxidant. Hypertension. 2008;51:211–217
- . Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circulation Research. 2001;88:E14–E22
- . Interaction between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovascular Research. 1999;43:562–571
- . Diabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008;295:L727–L732
- . Protein measurement with the folin phenol reagent. The Journal of Biological Chemistry. 1951;193:265–275
- . Role of efficacy in the assessment of the actions of alpha-adrenoceptor agonists in rat aorta with endothelium. Journal of Pharmacy and Pharmacology. 1986;38:209–213
- . AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells. Role of p22phox subunit. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28:878–885
- . Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor-kB-binding sites. The Journal of Biological Chemistry. 1998;273:22201–22208
- . Inhibition of NAD(P)H oxidase alleviates impaired NOS-dependent responses of pial arterioles in type 1 diabetes mellitus. Microcirculation. 2006;13:567–575
- . Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Atherosclerosis. 2007;192:15–24
- . Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. Clinical Science (Lond). 1994;87:31–36
- . Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1992;35:771–776
- . Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension. Pharmacological Reports. 2009;61:116–122
- . Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat. Life Sciences. 1996;58:PL147–PL152
- . The role of inflammation on atherosclerosis, intermediate and clinical cardiovascular endpoints in type 2 diabetes mellitus. European Journal of Internal Medicine. 2009;20:253–260
- . The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress. Toxicology and Applied Pharmacology. 2006;212:179–187
- . The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress. Toxicology and Applied Pharmacology. 2008;228:277–285
- . Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy. Circulation. 2001;104:1767–1772
- . Oxidative stress, AGE, and atherosclerosis. Kidney International Supplement. 2007;72:S17–S26
- . Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation. 2002;105:1429–1435
- . Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells. Diabetologia. 2004;47:1727–1734
- . Antiarthritic activity of the newly developed neutrophil oxidative burst antagonist apocynin. Free Radical Biology and Medicine. 1990;9:127–131
- . Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacological Reviews. 1992;44:103–150
- . Apocynin, NADPH oxidase, and vascular cells: a complex matter. Hypertension. 2008;51:172–174
- . Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells. Biochimica et Biophysica Acta. 2005;1722:143–147
- . Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Free Radical Biology and Medicine. 2005;39:381–391
☆ The study was supported by the Turkish Diabetes Foundation and the Research Fund of Ege University (Project no: 03-TIP-013).
PII: S1056-8727(10)00020-6
doi: 10.1016/j.jdiacomp.2010.02.001
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Diabetes and Its Complications
Volume 24, Issue 6
, Pages 415-423
, November 2010
