Journal of Diabetes and Its Complications
Volume 25, Issue 1 , Pages 31-38 , January 2011

Role of lipoic acid on insulin resistance and leptin in experimentally diabetic rats

  • Mohammed A. Kandeil

      Affiliations

    • Biochemistry Department, Faculty of Veterinary Medicine, Beni Suef University, Egypt
    • ,
  • Kamal A. Amin

      Affiliations

    • Biochemistry Department, Faculty of Veterinary Medicine, Beni Suef University, Egypt
    • Corresponding Author InformationCorresponding author. Biochemistry Department, College of Veterinary Medicine, Beni Suef University, Egypt. Fax: +20 00220822327982.
    • ,
  • Kamel A. Hassanin

      Affiliations

    • Biochemistry Department, Faculty of Veterinary Medicine, Beni Suef University, Egypt
    • ,
  • Kalid M. Ali

      Affiliations

    • Physiology Department, Faculty of Veterinary Medicine, Beni Suef University, Egypt
    • ,
  • Eman T. Mohammed

      Affiliations

    • Biochemistry Department, Faculty of Veterinary Medicine, Beni Suef University, Egypt

Received 12 August 2009 ,Revised 11 September 2009 ,Accepted 28 September 2009.

References 

  1. Abdel-Azim SA, Bader AM, Barakat MA. Effect of metformin, glyburide, and/or selenium on glucose homeostasis, lipid peroxidation, glutathione levels and changes in glutathione peroxidase activity in streptozotocin-induced diabetic rats. The Egyptian Journal of Biochemistry. 2002;20:393–411
  2. Abdel-Reheim, E. S. (1997). The effect of Nigella sativa on the glycemic state and immune response of diabetic albino rat. M.Sc. Thesis, Faculty of Science, Cairo University.
  3. Arivazhagan P, Panneerselvam SR, Panneerselvam C. Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and lipids in aged rats. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2003;58(9):B788–B791
  4. Barber M, Kasturi BS, Austin ME, Patel KP, MohanKumara SM, MohanKumara PS. Diabetes-induced neuroendocrine changes in rats: Role of brain monoamines, insulin and leptin. Brain Research. 2003;964:128–135
  5. Barr VA, Malid ED, Zarnowski MJ, Taylor SI, Cushman SW. Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology. 1997;138:4463–4472
  6. Beck-Nielsen H. Insulin resistance: Organ manifestations and cellular mechanisms. Ugeskrift for laeger. 2002;164(16):2130–2135
  7. Bhatti F, Mankhey RW, Asico L, Quinn MT, Welch WJ, Maric C. Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and non-diabetic kidney. Kidney International. 2005;67(4):1371–1380
  8. Biessels GJ, Kappelle AC, Bravenboer B, Erkelens DW, Gispen WH. Cerebral function in diabetes mellitus. Diabetologia. 1994;37:643–650
  9. Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. General Pharmacology. 1997;29:315–331
  10. Bitar MS, Wahid S, Pilcher CW, Al-Saleh E, Al-Mulla F. Alpha-lipoic acid mitigates insulin resistance in Goto–Kakizaki rats. Hormone and Metabolic Research. 2004;36(8):542–549
  11. Caro JF. Effect of glyburide on carbohydrate metabolism and insulin action. The American Journal of Medicine. 1990;89(20):17S–24S
  12. Cho, K. J., Moon, H. E., Moini, H., Packer, L., Yoon, D. Y., & Chung, A. S., (2003). α-Lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways. c., Vol. 278, No. 37, 12, 34823–34833.
  13. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. The New England Journal of Medicine. 1996;334:292–295
  14. Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B. The ob gene and insulin: A relationship leading to clues to the understanding of obesity. Diabetes. 1995;44:1467–1470
  15. Del Prato S, Marchetti P. Beta- and alpha-cell dysfunction in type 2 diabetes. Hormone and Metabolic Research. 2004;36(11–12):775–781
  16. Dimpfel W, Spüler M, Pierau FK, Ulrich H. Thioctic acid induces dose-dependent sprouting of neurites in cultured rat neuroblastoma cells. Developmental Pharmacology and Therapeutics. 1990;14(3):193–199
  17. Frederich RC, Hamman A, Anderson S, Löllmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nature Medicine. 1995;1:1311–1314
  18. Friedman JM. Obesity in the new millennium. Nature. 2000;404:632–634
  19. Gold AH. The effect of diabetes and insulin on liver glycogen synthetase activation. The Journal of Biological Chemistry. 1970;245:903–905
  20. Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio Heart Study. Diabetes Care. 1997;20:1087–1092
  21. Hathout EH, Sharkey J, Racine M, Ahn D, Mace JW, Saad MF. Changes in plasma leptin during the treatment of diabetic ketoacidosis. The Journal of Clinical Endocrinol and Metabolism. 1999;84(12):4545–4548
  22. Hirose H, Lee YH, Inman Y, Nagasawa JHJ, Unger RH. Defective fatty acids-mediated beta-cell compensation in zucker diabetic fatty rats. Pathogenic implications for obesity dependent diabetes. The Journal of Biological Chemistry. 1996;271:5633–5637
  23. Hounsom L, Horrobin DF, Tritschler H, Corder R, Tomlinson DR. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Diabetologia. 1998;41(7):839–843
  24. Huerta MG. Adiponectin and leptin: Potential tools in the differential diagnosis of pediatric diabetes?. Reviews in Endocrine & Metabolic Disorders. 2006;7(3):187–196
  25. Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ, Dietze GJ, et al. The antioxidant insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes. 1996;45(8):1024–1029
  26. Khamaisi M, Rudich A, Potashnik R, Tritschler HJ, Gutman A, Bashan N. Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. Metabolism. 1999;48(4):504–510
  27. Khan AH, Pessin JE. Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways. Diabetologia. 2002;45:1475–1483
  28. Kirel B, Dogruel N, Korkmaz U, Kilic FS, Ozdamar K, Ucar B. Serum leptin levels in type 1 diabetic and obese children: Relation to insulin levels. Clinical Biochemistry. 2000;33(6):475–480
  29. Kocak G, Aktan F, Canbolat O, Ozogul C, Elbeg S, Yildizoglu-Ari N, et al. Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes. Diabetes, Nutrition & Metabolism. 2000;13(6):308–318
  30. Lauszus FF, Schmitz O, Vestergaard H, Klebe JG, Pedersen O. Serum leptin levels in pregnant women with type 1 diabetes mellitus. Acta Obstetricia et Gynecologica Scandinavica. 2001;80(7):596–601
  31. Lee WJ, Song KH, Koh EH, Won JC, Kim HS, Park HS, et al. α-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochemical and Biophysical Research Communications. 2005;332:885–891
  32. Levy JR, Stevens W. The effects of insulin, glucose, and pyruvate on the kinetics of leptin secretion. Endocrinology. 2001;142:3558–3562
  33. El Sawalhy MM, Raffat M. Effect of alpha lipoic acid on oxidative stress status in rat kidney subjected to ischemia/reperfusion injury. The Egyptian Journal of Biochemistry & Molecular Biology. 2007;25(1):59–76
  34. Malmstroem R, Taskinen MR, Karonen SL, Yki-Järvinen H. Insulin increases plasma leptin concentrations in normal subjects and patients with IDDM. Diabetologia. 1996;39:993–996
  35. Mathe D. Dyslipidemia and diabetes: Animal models. Diabete & Metabolisme. 1995;21(2):106–111
  36. Mazzone T, Foster D, Chait A. In vivo stimulation of low-density lipoprotein degradation by insulin. Diabetes. 1984;33:333–338
  37. Melhem MF, Craven PA, Liachenko J, DeRubertis FR. α-Lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. Journal of the American Society of Nephrology. 2002;13:108–116
  38. Minokoshi Y, Kim Y, Peroni O, Fryer L, Muller C, Carling D, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 2002;415:268–269
  39. Miyanaga F, Ogawa Y, Ebihara K, Hidaka S, Tanaka T, Hayashi S, et al. Leptin as an adjunct of insulin therapy in insulin-deficient diabetes. Diabetologia. 2003;46(10):1329–1337(Epub 2003 Aug 20)
  40. Moini H, Packer L, Saris NE. Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid. Toxicology and Applied Pharmacology. 2002;182(1):84–90
  41. Monnier L, Colette C, Percheron C, Descomps B. Insulin, diabetes and cholesterol metabolism. Comptes rendus des seances de la societe de biologie et de Ses Filiales. 1995;189(5):919–931
  42. Mueller WM, Stanhope KL, Gregoire F, Evans JL, Havel PJ. Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes. Obesity Research. 2000;8:530–539
  43. O' Meara NM, Devery RA, Owens PB, Johnson AH, Tomkin GH. Cholesterol metabolism in alloxan-induced diabetic rabbits. Diabetes. 1990;39:626–633
  44. Ohkuwa T, Sato Y, Naoi M. Hydroxyl-radical formation in diabetogenic rats induced by streptozotocin. Life Sciences. 1995;56:1789–1795
  45. Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17:888–895
  46. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology & Medicine. 1995;19:227–250
  47. Pusztai P, Prechl J, Somogy A, Szaleczky E, Feher J. Experimental models in research of the pathomechanism of diabetes mellitus. Orvosi Hetilap. 1996;137(34):1865–1869
  48. Quaschning T, Schomig M, Keller M, Thiery J, Nauck M, Chollmeyer P, et al. Non-insulin dependent diabetes mellitus and hypertriglyceridemia impair lipoprotein metabolism in chronic hemodialysis patients. Journal of the American Society of Nephrology. 1999;10(2):332–341
  49. Raju J, Gupta D, Rao AR, Yadava PK, Baquer NZ. Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Molecular and Cellular Biochemistry. 2001;224(1–2):45–51
  50. Richmond W. Enzymatic determination of cholesterol. Clinical Chemistry. 1973;19:1350–1356
  51. Rudzka-Kocjan A, Szarras-Czapnik M, B J, Ginalska-Malinowska M. Estimation of the correlation of insulin resistance and selected adipocytokines in children with simple obesity-preliminary study. Endokrynologia, Diabetologia I Choroby Przemiany Materii Wieku Rozwojowego: Organ Polskiego Towarzystwa Endokrynologow Dzieciecych. 2006;12(3):211–215
  52. Schedl HP, Wilson HD. Effects of diabetes on intestinal growth and hexose transport in the rat. The American Journal of Physiology. 1971;220:1739
  53. Schroeder MM, Belloto RJ, Hudson RA, McInerney MF. Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets. Immunopharmacology Immunotoxicology. 2005;27(1):109–122
  54. Sheela CG, Augusti KT. Antidiabetic effects of S-ally cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian Journal of Experimental Biology. 1992;30:523–526
  55. Sindelar DK, Havel PJ, Seeley RJ, Wilkinson CW, Woods SC, Schwartz MW. Low plasma leptin levels contribute to diabetic hyperphagia in rats. Diabetes. 1999;48:1275–1280
  56. Smith SR. The endocrinology of obesity. Endocrinology and Metabolism Clinics of North America. 1996;25:921–942
  57. Snedecor GW, Cochran WG. Statistical methods. Ames, IA, U.S.A: Iowa State University Press; 1980;
  58. Sobenin IA, Tertov VV, Orekhov AN. Characterization of chemical composition of native and modified low-density lipoprotein occurring in the blood of diabetic patients. International Angiology. 1994;13:78–83
  59. Soliman AT, Omar M, Assem HM, Nasr IS, Rizk MM, El Matary W, et al. Serum leptin concentrations in children with type 1 diabetes mellitus: Relationship to body mass index, insulin dose, and glycemic control. Metabolism. 2002;51(3):292–296
  60. Song KH, Lee WJ, Koh JM, Kim HS, Youn JY, Park HS, et al. Alpha-lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochemical and Biophysical Research Communications. Jan 7 2005;326(1):197–202
  61. Strödter D, Lehmann E, Lehmann U, Tritschler HJ, Bretzel RG, Federlin K. The influence of thioctic acid on metabolism and function of the diabetic heart. Diabetes Research and. Clinical Practice. 1995;29(1):19–26
  62. Szkudelski T. Intracellular mediators in regulation of leptin secretion from adipocytes. Physiological Research. 2006;(Dec 19)
  63. Szkudelski T, Kandulska K, Okulicz M. Alloxan in vivo does not only exert deleterious effects on pancreatic β-cells. Physiological Research. 1998;47:343–346
  64. Taniguchi A, Nakai Y, Sakai M, Yoshii S, Hamanaka D, Hatae Y, et al. Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients. Metabolism. 2002;51:544–548
  65. Trinder P. Enzymatic method for glucose estimation. Annals of Clinical Biochemistry. 1969;6:24
  66. Turkingto RW, Eslkowkski A, Link M. Secretion of insulin or connecting peptide; a predictor of insulin dependence of obese diabetics. Archives of Internal Medicine. 1982;142:1102–1105
  67. Wollin SD, Jones PJ. Alpha-lipoic acid and cardiovascular disease. The Journal of Nutrition. 2003;133:3327–3330
  68. Yi X, Maeda N. {alpha}-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes. 2006;55(8):2238–2244
  69. Yildiz BO, Haznedaroglu IC. Rethinking leptin and insulin action: Therapeutic opportunities for diabetes. The International Journal of Biochemistry & Cell Biology. 2006;38:820–830
  70. Young D, Pestaner L. Enzymatic determination of triacylglycerol in serum. Clinical Chemistry. 1975;21:5
  71. Younsozai MK, Schedl HP. Intestinal amino acid transport and tissue concentration in diabetes. The American Journal of Physiology. 1972;223:828

PII: S1056-8727(09)00098-1

doi: 10.1016/j.jdiacomp.2009.09.007

Journal of Diabetes and Its Complications
Volume 25, Issue 1 , Pages 31-38 , January 2011

Article Tools

* Image Usage & Resolution