Journal of Diabetes and Its Complications
Volume 24, Issue 6 , Pages 404-408 , November 2010

Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus

Received 27 July 2009 ,Accepted 28 September 2009.

References 

  1. Arner RJ, Prabhu KS, Reddy CC. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney. Biochemical and Biophysical Research Communications. 2004;324:1386–1392
  2. Arner RJ, Prabhu KS, Thompson JT, Hildenbrandt GR, Liken AD, Reddy CC. myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and d-chiro-inositol. Biochemical Journal. 2001;360:313–320
  3. Arner RJ, Prabhu KS, Krishnan V, Johnson MC, Reddy CC. Expression of myo-inositol oxygenase in tissue susceptible to diabetic complications. Biochemical and Biophysical Research Communications. 2006;339:816–820
  4. Cohen AM, Wald H, Popovtzer M, Rosenmann E. Effect of myo-inositol supplementation on the development of renal pathological changes in the Cohen diabetic (type 2) rat. Diabetologia. 1995;38:899–905
  5. Del Monte MA, Rabbani R, Diaz TC, Lattimer SA, Nakamura J, Brennan MC, et al. Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications. Diabetes. 1991;40:1335–1345
  6. Greene DA, Chakrabarti S, Lattimer SA, Sima AA. Role of sorbitol accumulation and myo-inositol depletion in paranodal swelling of large meylinated nerve fibers in the insulin-deficient spontaneously diabetic bio-breeding rat. Reversal by insulin replacement, an aldose reductase inhibitor, and myo-inositol. Journal of Clinical Investigation. 1987;79:1479–1485
  7. Heesom AE, Hibberd ML, Millward A, Demaine AG. Polymorphism in the 5′-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes. Diabetes. 1997;46:287–291
  8. Huang LC, Fonteles MC, Houston DB, Zhang C, Larner J. Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycaemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo. Endocrinology. 1993;132:652–657
  9. Kawa JM, Przybylski R, Taylor CG. Urinary chiro-Inositol and myo-Inositol excretion is elevated in the diabetic db/db mouse and streptozotocin diabetic rat. Experiemental Biology and Medicine. 2003;228:907–914
  10. Kennington AS, Hill CR, Craig J, Bogardus C, Raz I, Ortmeyer HK, et al. Low urinary chiroinositol excretion in non-insulin dependent diabetes mellitus. New England Journal of Medicine. 1990;323:373–378
  11. Larner J. d-chiro-inositol—its functional role in insulin action and its deficit in insulin resistance. International Journal of Experimental Diabetes Research. 2002;3:347–360
  12. Lin LR, Reddy VN, Giblin FJ, Kador PF, Kinoshita H. Polyol accumulation in cultured human lens epithelial cells. Experimental Eye Research. 1991;52:93–100
  13. Nayak B, Xie P, Akagi S, Yang Q, Sun L, Wada J, et al. Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high glucose ambience. Proceedings of the National Academy of Sciences, USA. 2005;102:17952–17957
  14. Ortmeyer HK, Bodkin NL, Lilley K, Larner J, Hansen BC. Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys. Endocrinology. 1993;132:640–645
  15. Ortmeyer HK, Huang LC, Zhang L, Hansen BC, Larner J. Chiroinositol deficiency and insulin resistance. II. Acute effects of d-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys. Endocrinology. 1993;132:646–651
  16. Ostlund RE, McGill JB, Herskowitz I, Kipnis DM, Santiago JV, Sherman WR. d-chiro-inositol metabolism in diabetes mellitus. Proceedings of the National Academy of Sciences, USA. 1993;90:9988–9992
  17. Prabhu KS, Arner RJ, Vunta H, Redddy CC. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. Journal of Biological Chemistry. 2005;280:19895–19901
  18. Raccah D, Coste T, Cameron NE, Dufayet D, Vague P, Hohman TC. Effect of the aldose reductase inhibitor tolrestat on nerve conduction velocity, Na/K ATPase activity, and polyols in red blood cells, sciatic nerve, kidney cotex, and kidney medulla of diabetic rats.. Journal of Diabetes and Its Complications. 1998;12:154–162
  19. The Expert Committee On The Diagnosis And Classification Of Diabetes Mellitus . Report of the Expert Committee On The Diagnosis And Classification Of Diabetes Mellitus. Diabetes Care. 2003;26(Suppl. 1):S5–S20
  20. Tiwari JL, Terasaki PI. In:  Tiwari JL,  Terasaki PI editor. The data and statistical analysis in HLA and disease association. New York, NY: Springer-Verlag Press; 1985;p. 18–27
  21. Yang Q, Dixit B, Wada J, Tian Y, Wallner EI, Srivastva SK, et al. Identification of a renal-specific oxido-reductase in newborn diabetic mice. Proceedings of the National Academy of Sciences, USA. 2000;97:9896–9901

PII: S1056-8727(09)00096-8

doi: 10.1016/j.jdiacomp.2009.09.005

Journal of Diabetes and Its Complications
Volume 24, Issue 6 , Pages 404-408 , November 2010

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