Journal of Diabetes and Its Complications
Volume 24, Issue 4 , Pages 286-288 , July 2010

Alpha tocopherol use in the management of diabetic cardiomyopathy: lessons learned from randomized clinical trials

  • Turgay Celik

      Affiliations

    • Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik-Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Department of Cardiology, Gulhane School of Medicine, 06018 Etlik-Ankara, Turkey. Tel.: +90 312 3044268; fax: +90 312 3044250.
  • ,
  • Cagdas Yuksel

      Affiliations

    • Department of Cardiology, Sarikamis Army District Hospital, Sarikamis, Turkey
  • ,
  • Atila Iyısoy

      Affiliations

    • Department of Cardiology, School of Medicine, Gulhane Military Medical Academy, Etlik-Ankara, Turkey

Received 24 November 2008 ,Revised 4 February 2009 ,Accepted 18 February 2009.

References 

  1. Asbun J, Villarreal FJ. The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. Journal of American College of Cardiology. 2006;47:693
  2. Ashrafian H, Frenneaux MP, Opie LH. Metabolic mechanisms in heart failure. Circulation. 2007;116:434
  3. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA. 2007;297:842–857
  4. Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. New England Journal of Medicine. 2001;345:1583–1592
  5. Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation. 2007;115:3212–3223
  6. Bowry VW, Ingold KU, Stocker R. Vitamin E in human low-density lipoproteins: When and how this antioxidant becomes a pro-oxidant. Biochemical Journal. 1992;288:341–344
  7. Bucala R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. Journal of Clinical Investigation. 1991;87:432–438
  8. Galderisi M, Anderson KM, Wilson PW, Levy D. Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (The Framingham Heart Study). American Journal of Cardiology. 1991;68:85–89
  9. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilatation in patients with insulin-dependent diabetes mellitus. Circulation. 1993;88:2510–2516
  10. Keith M, Geranmayegan A, Sole MJ, Kurian R, Robinson A, Omran AS, et al. Increased oxidative stress in patients with congestive heart failure. Journal of the American College Cardiology. 1998;31:1352–1356
  11. Keith ME, Jeejeebhoy KN, Langer A, Kurian R, Barr A, O'Kelly B, et al. A controlled clinical trial of vitamin E supplementation in patients with congestive heart failure. American Journal of Clinical Nutrition. 2001;73:219–224
  12. Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial. Journal of the American Medical Association. 2005;293:1338–1347
  13. Marchioli R, Levantesi G, Macchia A, Marfisi RM, Nicolosi GL, Tavazzi L, et al. Vitamin E increases the risk of developing heart failure after myocardial infarction: Results from the GISSI-Prevenzione trial. Journal of Cardiovascular Medicine (Hagerstown). 2006;7:347–350
  14. McMurray J, Chopra M, Abdullah I, Smith WE, Dargie HJ. Evidence of oxidative stress in chronic heart failure in humans. European Heart Journal. 1993;14:1493–1498
  15. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: High dosage vitamin E supplementation may increase all cause mortality. Annals of Internal Medicine. 2005;142:37–46
  16. Rodrigues B, Cam MC, McNeill JH. Myocardial substrate metabolism: Implications for diabetic cardiomyopathy. Journal of Molecular and Cellular Cardiology. 1995;27:169–179
  17. Scognamiglio R, Avogaro A, Casara D, Crepaldi C, Marin M, Palisi M, et al. Myocardial dysfunction and adrenergic cardiac innervation in patients with insulin-dependent diabetes mellitus. Journal of the American College Cardiology. 1998;31:404–412
  18. Shirpoor A, Salami S, Khadem-Ansari MH, Ilkhanizadeh B, Pakdel FG, Khademvatani K. Cardioprotective effect of vitamin E: Rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat. Journal of Diabetes and Its Complications. 2008, April;(Electronic publication ahead of print)
  19. Stone PH, Muller JE, Hartwell T, York BJ, Rutherford JD, Parker CB, et al The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: Contribution of both coronary disease and left ventricular dysfunction to the adverse prognosis. The MILIS Study Group. Journal of the American College Cardiology. 1989;14:49–57
  20. Tousoulis D, Antoniades C, Vassiliadou C, Toutouza M, Pitsavos C, Tentolouris C, et al. Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure. European Journal Heart Failure. 2005;7:1126–1132
  21. Yoon YS, Uchida S, Masuo O, Cejna M, Park JS, Gwon HC, et al. Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: Restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation. 2005;111:2073–2085
  22. Zarich S, Nesto R. Diabetic cardiomyopathy. American Heart Journal. 1989;118:1000–1012

PII: S1056-8727(09)00028-2

doi: 10.1016/j.jdiacomp.2009.02.005

Journal of Diabetes and Its Complications
Volume 24, Issue 4 , Pages 286-288 , July 2010