Journal of Diabetes and Its Complications
Volume 24, Issue 2 , Pages 90-95 , March 2010

Erythropoietin response to anemia and its association with autonomic neuropathy in type 2 diabetic patients without advanced renal failure

  • Mee Kyoung Kim

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    • These authors equally contributed to this work.
    • ,
  • Ki Hyun Baek

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    • These authors equally contributed to this work.
    • ,
  • Dong Jun Lim

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    • ,
  • Young Kyu Kim

      Affiliations

    • Department of Preventive Medicine, The Catholic University of Korea, Seoul, Korea
    • ,
  • Moo-Il Kang

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    • ,
  • Kwang-Woo Lee

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    • ,
  • Ki-Ho Song

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    • Corresponding Author InformationCorresponding author. Department of Internal Medicine, St. Mary's Hospital, The Catholic University of Korea, 62 Yoido-dong Youngdeungpo-gu, Seoul 150-713, Korea. Tel.: +82 2 3779 1557; fax: +82 2 780 3132.

Received 10 December 2008 ,Accepted 4 February 2009.

References 

  1. Biaggioni I, Robertson D, Krantz S, Jones M, Haile V. The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Annals of Intern Medicine. 1994;121:181–186
  2. Bosman DR, Osborne CA, Marsden JT, Macdougall IC, Gardner WN, Watkins PJ. Erythropoietin response to hypoxia in patients with diabetic autonomic neuropathy and non-diabetic chronic renal failure. Diabetic Medicine. 2002;19:65–69
  3. Bosman DR, Winkler AS, Marsden JT, Macdougall IC, Watkins PJ. Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. Diabetes Care. 2001;24:495–499
  4. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, et al. American Diabetes Association. Diabetic neuropathies: A statement by the American Diabetes Association. Diabetes Care. 2005;28:956–962
  5. Bruno CM, Sciacca C, Bertino G, Cilio D, Pellicano R, Marchese AE, et al. Circulating erythropoietin in microalbuminuric type 2 diabetic patients with normal renal function: A pilot study. Journal of Diabetes and Its Complications. 2006;20:376–379
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  8. Ferrucci L, Guralnik JM, Bandinelli S, Semba RD, Lauretani F, Corsi A, et al. Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. British Journal of Haematology. 2007;136:849–855
  9. Jermendy G, Tóth L, Vörös P, Koltai MZ, Pogátsa G. Cardiac autonomic neuropathy and QT interval length. A follow-up study in diabetic patients. Acta Cardiologica. 1991;46:189–200
  10. McGill JB, Bell DS. Anemia and the role of erythropoietin in diabetes. Journal of Diabetes and Its Complications. 2006;20:262–272
  11. Radtke HW, Claussner A, Erbes PM, Scheuermann EH, Schoeppe W, Koch KM. Serum erythropoietin concentration in chronic renal failure: Relationship to degree of anemia and excretory renal function. Blood. 1979;54:877–884
  12. Smith SA. Reduced sinus arrhythmia in diabetic autonomic neuropathy: Diagnostic value of an age-related normal range. British Medical Journal. 1982;285:1599–1601
  13. Spallone V, Maiello MR, Kurukulasuriya N, Barini A, Lovecchio M, Tartaglione R, et al. Does autonomic neuropathy play a role in erythropoietin regulation in non-proteinuric Type 2 diabetic patients?. Diabetic Medicine. 2004;21:1174–1180
  14. Symeonidis A, Kouraklis-Symeonidis A, Psiroyiannis A, Leotsinidis M, Kyriazopoulou V, Vassilakos P, et al. Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus. Annals of Hematology. 2006;85:79–85
  15. Thomas MC, MacIsaac RJ, Tsalamandris C, Power D, Jerums G. Unrecognized anemia in patients with diabetes: A cross-sectional survey. Diabetes Care. 2003;26:1164–1169
  16. Vervoort G, Willems HL, Wetzels JF. Assessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients: Validity of a new (MDRD) prediction equation. Nephrology, Dialysis, Transplantation. 2002;17:1909–1913
  17. Wallach J. Core blood analytes: Alterations by disease. In:  Seigafuse S,  Winter N,  Konstant D editor. Interpretation of diagnostic tests. 8th ed.. Philadelphia, PA: Lippincott Williams & Wilkins; 2007;p. 55
  18. Winkler AS, Marsden J, Chaudhuri KR, Hambley H, Watkins PJ. Erythropoietin depletion and anaemia in diabetes mellitus. Diabetic Medicine. 1999;16:813–819

PII: S1056-8727(09)00026-9

doi: 10.1016/j.jdiacomp.2009.02.002

Journal of Diabetes and Its Complications
Volume 24, Issue 2 , Pages 90-95 , March 2010

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