Journal of Diabetes and Its Complications
Volume 24, Issue 2 , Pages 102-108 , March 2010

Association of the functional A118G polymorphism of OPRM1 in diabetic patients with foot ulcer pain

  • Kuang-I Cheng

      Affiliations

    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Faculty of Medicine, Department of Anesthesiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  • ,
  • Shiu-Ru Lin

      Affiliations

    • Department of Medical Research, Fooyin University and Hospital, Kaohsiung, Taiwan
  • ,
  • Lin-Li Chang

      Affiliations

    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan
  • ,
  • Jaw-Yuan Wang

      Affiliations

    • Division of General and Gastroenterologic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Faculty of Medicine, Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationCorresponding authors. Faculty of Medicine, Department of Surgery, College of Medicine, Kaohsiung Medical University, 100 Shin-Chuan 1st Road, Kaohsiung 807, Taiwan. Tel.: +886 7 3121101x7676; fax: +886 7 3111482.
    • Chung-Sheng Lai and Jaw-Yuan Wang contributed equally to this article.
  • ,
  • Chung-Sheng Lai

      Affiliations

    • Faculty of Medicine, Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Corresponding Author InformationCorresponding authors. Faculty of Medicine, Department of Surgery, College of Medicine, Kaohsiung Medical University, 100 Shin-Chuan 1st Road, Kaohsiung 807, Taiwan. Tel.: +886 7 3121101x7676; fax: +886 7 3111482.
    • Chung-Sheng Lai and Jaw-Yuan Wang contributed equally to this article.

Received 30 July 2008 ,Revised 22 December 2008 ,Accepted 4 February 2009.

References 

  1. Abetz L, Sutton M, Brady L, McNulty P, Gagnon D. The Diabetic Foot Ulcer Scale (DFS): A quality of life instrument for use in clinical trials. Practical Diabetes International. 2002;19:167–175
  2. Bond C, LaForge KS, Tian M, Melia D, Zhang S, et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:9608–9613
  3. Boulton AJ, Gries FA, Jervell JA. Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy. Diabetic Medicine. 1998;15:508–514
  4. Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Davignon DR, Smith DG. A prospective study of risk factors for diabetic foot ulcer. The Seattle Diabetic Foot Study. Diabetes Care. 1999;22:1036–1042
  5. Carrington AL, Mawdsley SK, Morley M, Kincey J, Boulton AJ. Psychological status of diabetic people with or without lower limb disability. Diabetes Research and Clinical Practice. 1996;32:19–25
  6. Chou WY, Yang LC, Lu HF, Ko JY, Wang CH, et al. Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiologica Scandinavica. 2006;50:787–792
  7. Crowley JJ, Oslin DW, Patkar AA, Gottheil E, DeMaria PA, et al. A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatric Genetics. 2003;13:169–173
  8. Dolan NC, Liu K, Criqui MH, Greenland P, Guralnik JM, et al. Peripheral artery disease, diabetes, and reduced lower extremity functioning. Diabetes Care. 2002;25:113–120
  9. Evans AR, Pinzur MS. Health-related quality of life of patients with diabetes and foot ulcers. Foot & Ankle International. 2005;26:32–37
  10. Faglia E, Mantero M, Caminiti M, Caravaggi C, De Giglio R, et al. Extensive use of peripheral angioplasty, particularly infrapopliteal, in the treatment of ischaemic diabetic foot ulcers: Clinical results of a multicentric study of 221 consecutive diabetic subjects. Journal of Internal Medicine. 2002;252:225–232
  11. Fillingim RB, Kaplan L, Staud R, Ness TJ, Glover TL, et al. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. Journal of Pain. 2005;6:159–167
  12. Freedman G, Cean C, Duron V, Tarnovskaya A, Brem H. Pathogenesis and treatment of pain in patients with chronic wounds. Surgical Technology International. 2003;11:168–179
  13. Gregg EW, Sorlie P, Paulose-Ram R, Gu Q, Eberhardt MS, et al. Prevalence of lower-extremity disease in the US adult population ≥40 years of age with and without diabetes: 1999–2000 national health and nutrition examination survey. Diabetes Care. 2004;27:1591–1597
  14. Grosch S, Niederberger E, Lotsch J, Skarke C, Geisslinger G. A rapid screening method for a single nucleotide polymorphism (SNP) in the human MOR gene. British Journal of Clinical Pharmacology. 2001;52:711–714
  15. Janicki PK, Schuler G, Francis D, Bohr A, Gordin V, et al. A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain. Anesthesia and Analgesia. 2006;103:1011–1017
  16. Kim SG, Kim CM, Kang DH, Kim YJ, Byun WT, et al. Association of functional opioid receptor genotypes with alcohol dependence in Koreans. Alcoholism, Clinical and Experimental Research. 2004;28:986–990
  17. Kiziltan ME, Gunduz A, Kiziltan G, Akalin MA, Uzun N. Peripheral neuropathy in patients with diabetic foot ulcers: Clinical and nerve conduction study. Journal of Neurological Sciences. 2007;258:75–79
  18. Landau R, Cahana A, Smiley RM, Antonarakis SE, Blouin JL. Genetic variability of mu-opioid receptor in an obstetric population. Anesthesiology. 2004;100:1030–1033
  19. Lotsch J, Stuck B, Hummel T. The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation. Behavioral Neuroscience. 2006;120:1218–1224
  20. Low PA, Dotson RM. Symptomatic treatment of painful neuropathy. JAMA. 1998;280:1863–1864
  21. Mayfield JA, Reiber GE, Sanders LJ, Janisse D, Pogach LM. Preventive foot care in people with diabetes. Diabetes Care. 2003;26:S78–S79
  22. Nishizawa D, Han W, Hasegawa J, Ishida T, Numata Y, et al. Association of micro-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Neuropsychobiology. 2006;53:137–141
  23. Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ. A comparison of two diabetic foot ulcer classification systems: The Wagner and the University of Texas wound classification systems. Diabetes Care. 2001;24:84–88
  24. Reddy M, Kohr R, Queen D, Keast D, Sibbald RG. Practical treatment of wound pain and trauma: A patient-centered approach. An overview.. Ostomy/Wound Management. 2003;49:2–15
  25. Ribu L, Rustoen T, Birkeland K, Hanestad BR, Paul SM, Miaskowski C. The prevalence and occurrence of diabetic foot ulcer pain and its impact on health-related quality of life. Journal of Pain. 2006;7:290–299
  26. Ribu L, Wahl A. Living with diabetic foot ulcers: A life of fear, restrictions, and pain. Ostomy/Wound Management. 2004;50:57–67
  27. Rijken PM, Dekker J, Dekker E, Lankhorst GJ, Bakker K, et al. Clinical and functional correlates of foot pain in diabetic patients. Disability and Rehabilitation. 1998;20:330–336
  28. Sia AT, Lim Y, Lim EC, Goh RW, Law HY, et al. A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology. 2008;109:520–526
  29. Sibbald RG, Armstrong DG, Orsted HL. Pain in diabetic foot ulcers. Ostomy/Wound Management. 2003;49:24–29
  30. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA. 2005;293:217–228
  31. Tan EC, Tan CH, Karupathivan U, Yap EP. Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport. 2003;14:569–572
  32. Ulbrecht JS, Cavanagh PR, Caputo GM. Foot problems in diabetes: An overview. Clinical Infectious Diseases. 2004;39:S73–S82
  33. Wand GS, McCaul M, Yang X, Reynolds J, Gotjen D, et al. The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology. 2002;26:106–114
  34. Zadina JE, Hackler L, Ge LJ, Kastin AJ. A potent and selective endogenous agonist for the mu-opiate receptor. Nature. 1997;386:499–502

PII: S1056-8727(09)00024-5

doi: 10.1016/j.jdiacomp.2009.02.003

Journal of Diabetes and Its Complications
Volume 24, Issue 2 , Pages 102-108 , March 2010