Journal of Diabetes and Its Complications
Volume 24, Issue 2 , Pages 115-120 , March 2010

Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians

  • Marcio F. Vendramini

      Affiliations

    • Division of Endocrinology, Department of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Alexandre C. Pereira

      Affiliations

    • Heart Institute (InCor), São Paulo University Medical School, University of São Paulo, SP, Brazil
    • ,
  • Sandra R. Ferreira

      Affiliations

    • School of Public Health, University of Sao Paulo, São Paulo, SP, Brazil
    • ,
  • Teresa S. Kasamatsu

      Affiliations

    • Division of Endocrinology, Department of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
    • ,
  • Regina S. Moisés

      Affiliations

    • Division of Endocrinology, Department of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
    • Corresponding Author InformationCorresponding author. Escola Paulista de Medicina, Disciplina de Endocrinologia, Universidade Federal de São Paulo, Rua Botucatu, 740-2, andar, 04034-970 São Paulo, SP, Brazil. Tel.: +55 11 5576 4229; fax: +55 11 5579 6636.
    • ,
  • Japanese Brazilian Diabetes Study Group

Received 28 April 2008 ,Revised 10 January 2009 ,Accepted 21 January 2009.

References 

  1. Alberti KGMM, Zimmet PZ for the World Health Organization Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Report of a WHO Consultation. Geneva: WHO; 1999;
  2. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications. 1999;257:79–83
  3. Gimeno SGA, Ferreira SRG, Franco LJ, Hirai AT, Matsumura L, Moisés RS. Prevalence and 7-year incidence of type II diabetes mellitus in a Japanese-Brazilian population: an alarming public health problem. Diabetologia. 2002;45:1635–1638
  4. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 2002;51:536–540
  5. Heidi IM, Wagner SA, Gohlke H, Iglseder B, Mueller JC, Cip P, et al. Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians. Diabetes. 2006;55:375–384
  6. Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, et al. Common variants in the adiponectin level (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits. The Framingham Offspring Study. Diabetes. 2008;57:3353–3359
  7. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis Thrombosis, and Vascular Biology. 2000;20:1595–1599
  8. Jang Y, Lee JH, Kim OY, Koh SJ, Chae JS, Woo JH, et al. The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. Metabolism. 2006;55:59–66
  9. Kishida K, Nagaretani H, Kondo H, Kobayashi H, Tanaka S, Maeda N, et al. Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochemical and Biophysical Research Communications. 2003;306:286–292
  10. Kissebah AH, Sonnenberg GE, Mykleubus J, Goldstein M, Broman K, James RG, et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2000;97:14478–14483
  11. Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, et al. Association of adiponectin mutation with type 2 diabetes—a candidate gene for the insulin resistance syndrome. Diabetes. 2002;51:2325–2328
  12. In:  Lewin B editors. Genes. New York: Oxford Univ. Press; 1997;
  13. Marquezine GE, Pereira AC, Sousa AG, Mill JG, Hueb WA, Krieger JE. TCF7L2 variant genotype and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population. BMC Molecular Biology. 2008;9:106
  14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  15. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes. 2002;51:2306–2312
  16. Menzaghi C, Trischitta V, Doria A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes. 2007;56:1198–1209
  17. Nakatani K, Noma K, Nishioka J, Kasai Y, Morioka K, Katsuki A, et al. Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects. International Journal of Molecular Medicine. 2005;15:173–177
  18. Ohashi K, Ouchi N, Kihara S, Funahashi T, Nakamura T, Sumitsuji S, et al. Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. Journal of the American College of Cardiology. 2004;43:1195–1200
  19. Schaffler A, Barth N, Palitzsch KD, Drobnik W, Scholmerich J, Schmitz G. Mutation analysis of the human adipocyte-specific apM-1 gene. European Journal of Clinical Investigation. 2000;30:879–887
  20. Shin MJ, Jang Y, Koh SJ, Kim OY, Lee JE, Ordovas JM. The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. International Journal of Obesity. 2006;30:1702–1708
  21. Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, et al. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity—interaction with family history of type 2 diabetes. Diabetes. 2002;51:37–41
  22. Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, et al. Genomic structure and mutations in adipose-specific gene, adiponectin. International Journal of Obesity and Related Metabolic Disorders. 2000;24:861–868
  23. Tso AW, Sham PC, Wat NM, Xu A, Cheung BM, Rong R, et al. Polymorphisms in the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study. Diabetologia. 2006;49:1806–1815
  24. Vasseur F, Leprêtre F, Lacquemant C, Froguel P. The genetics of adiponectin. Current Diabetes Report. 2003;3:151–158
  25. Vendramini MF, Ferreira SRG, Gimeno SGA, Kasamatsu TS, Miranda WL, Moisés RS. Plasma adiponectin levels and incident glucose intolerance in Japanese-Brazilians: a seven-year follow-up study. Diabetes Research and Clinical Practice. 2006;73:304–309
  26. Vionnet N, Hani E, Dupont S, Gallina S, Francke S, Dotte S, et al. Genome-wide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of type 2 diabetes locus on chromosome 1q21-q24. American Journal of Human Genetics. 2000;67:1470–1480
  27. Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. Journal of Biological Chemistry. 2003;278:40352–40363
  28. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism. 2001;86:1930–1935
  29. Woo JG, Dolan LM, Deka R, Kaushal RD, Shen Y, Pal P, et al. Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes. 2006;55:523–529

PII: S1056-8727(09)00005-1

doi: 10.1016/j.jdiacomp.2009.01.007

Journal of Diabetes and Its Complications
Volume 24, Issue 2 , Pages 115-120 , March 2010

Article Tools

* Image Usage & Resolution