Journal of Diabetes and Its Complications
Volume 24, Issue 4 , Pages 229-233 , July 2010

Gabapentin therapy improves heart rate variability in diabetic patients with peripheral neuropathy

  • Necip Ermis

      Affiliations

    • Cardiology Department, Baskent University Medical School, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Cardiology Department, Adana Teaching and Medical Research Center, Baskent University, 01250 Yuregir, Adana, Turkey. Tel.: +90 322 3272727x2094; fax: +90 322 3271274.
  • ,
  • Hakan Gullu

      Affiliations

    • Cardiology Department, Baskent University Medical School, Ankara, Turkey
  • ,
  • Mustafa Caliskan

      Affiliations

    • Cardiology Department, Baskent University Medical School, Ankara, Turkey
  • ,
  • Aydan Unsal

      Affiliations

    • Endocrinology Department, Baskent University Medical School, Ankara, Turkey
  • ,
  • Mustafa Kulaksizoglu

      Affiliations

    • Endocrinology Department, Baskent University Medical School, Ankara, Turkey
  • ,
  • Haldun Muderrisoglu

      Affiliations

    • Cardiology Department, Baskent University Medical School, Ankara, Turkey

Received 15 July 2008 ,Revised 26 September 2008 ,Accepted 3 December 2008.

References 

  1. Adriaensen H, Plagkhi L, Mathieu C, Joffroy A, Vissers K. Critical review of oral drug treatments for diabetic neuropathic pain — clinical outcomes based on efficacy and safety data from placebo-controlled and direct comparative studies. Diabetes/Metabolism Research and Reviews. 2005;21:231–240
  2. Arikkath J, Cambell KP. Auxillary subunits: Essential components of the voltage-gated calcium channel complex. Current Opinion in Neurobiology. 2003;13:298–307
  3. Bernardi L, Ricordi L, Lazzari P, Solda P, Calciati A, Ferrari MR, et al. Impaired circadian modulation of sympathovagal activity in diabetes. A possible explanation for altered temporal onset of cardiovascular disease. Circulation. 1992;86:1443–1452
  4. Burger AJ, Weinrauch LA, Delia JA, Aronson D. Effects of glycemic control on heart rate variability in type I diabetic patients with cardiac autonomic neuropathy. American Journal of Cardiology. 1999;84:687–691
  5. Dietrich DF, Schindler C, Schwartz J, Barthelemy JC, Tschopp JM, Roche F. Heart rate variability in an ageing population and its association with lifestyle and cardiovascular risk factors: Results of the SPALDIA study. Europace. 2006;8:521–529
  6. Dooley DJ, Donovan CM, Meder WP, Whetzel SZ. Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: Inhibition of K+ evoked [3H]-norepinephrine release from rat neocortical slices. Synapse. 2002;45:171–190
  7. Ebbehoj E, Poulsen PL, Hansen KW, Knudsen ST, Molgaard H, Mogensen CE. Effects on heart rate variability of metoprolol supplementary to on going ACE-inhibitor treatment in type I diabetic patients with abnormal albuminuria. Diabetologia. 2002;45:965–975
  8. Fehrenbacher JC, Taylor CP, Vasko MR. Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C. Pain. 2003;105:133–141
  9. Fink K, Meder W, Dooley DJ, Gothert M. Inhibition of neuronal Ca (2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. British Journal of Pharmacology. 2000;130:900–906
  10. Gilron I, Flatters SJ. Gabapentin and pregabalin for the treatment of neuropathic pain: A review of laboratory and clinical evidence. Pain Research & Management. 2006;11(Suppl):16A–29A
  11. Gong HC, Hang J, Kohler W, Li L, Su TZ. Tissue-specific expression and gabapenting binding properties of calcium channel α2γ subunit subtypes. Journal of Membrane Biology. 2001;184:35–44
  12. Kontopoulos AG, Athyros VG, Didangelos TP, Papageorgiou AA, Avramidis MJ, Mayroudi MC, et al. Effect of chronic quinapril administration on heart rate variability in patients with diabetic autonomic neuropathy. Diabetes Care. 1997;20:355–361
  13. Lanneau C, Green A, Hirst WD, Wise A, Brown JT, Donnier E, et al. Gabapetin is not a GABA B receptor agonist. Neuropharmacology. 2001;41:965–975
  14. Makimattila S, Schlenzka A, Mantysaarı M, Bergholm R, Summanen P, Saar P. Predictors of abnormal cardiovascular autonomic function measured by frequency domain analysis of heart rate variability and conventional tests in patients with type 1 diabetes. Diabetes Care. 2000;23(11):1686–1693
  15. Marais E, Klugbauer N, Hoffman F. Calcium channel α2γ subunits—structure and gabapentin binding. Molecular Pharmacology. 2001;59:1243–1248
  16. Meijer JMW, Bosma E, Lefrandt JD, Links TP, Smit AJ, Stewart RE. Clinical diagnosis of diabetic polyneuropathy with the diabetic neuropathy symptom and diabetic neuropathy examination scores. Diabetes Care. 2003;26:697–701
  17. Nicholsan B. Gabapentin use in neropathic pain syndromes. Acta Neurologica Scandinavica. 2000;101:359–371
  18. Pagani M, Malfatto G, Pierini S, Casati R, Masu AM, Poli M, et al. Spectral analysis of heart rate variability in the assessment of autonomic diabetic neuropathy. Journal of the Autonomic Nervous System. 1988;23:143–153
  19. Sills GJ. The mechanisms of action of gabapentin and pregabalin. Current Opinion in Pharmacology. 2006;6:108–113
  20. Task force of the European Society of Cardiologythe North American Society of Pacing and Electrophysiology. Heart rate variability, standards of measurement, physiological interpretation and clinical use. European Heart Journal. 1996;17:354–381
  21. Taylor C. The biology and pharmacology of calcium channel alpha 2-delta proteins. CNS Drug Reviews. 2004;10:183–188
  22. Vinik AI, Erbas T. Recognizing and treating diabetic autonomic neuropathy. Cleveland Clinic Journal of Medicine. 2001;68:928–944
  23. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care. 2003;26:1553–1579
  24. Ziegler D. Cardiovascular autonomic neuropathy: Clinical manifestations and measurement. Diabetes Reviews. 1999;7:300–315
  25. Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: Current evidence from clinical trials. Experimental and Clinical Endocrinology & Diabetes. 1999;107:421–430

PII: S1056-8727(08)00120-7

doi: 10.1016/j.jdiacomp.2008.12.001

Journal of Diabetes and Its Complications
Volume 24, Issue 4 , Pages 229-233 , July 2010