Journal of Diabetes and Its Complications
Volume 23, Issue 3 , Pages 160-166 , May 2009

Cardiorespiratory capacity is associated with favourable cardiovascular risk profile in patients with Type 2 diabetes

  • Nikolaos P.E. Kadoglou

      Affiliations

    • 1st Department of Internal Medicine, “Hippokratio” General Hospital of Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author. 124 Vosporou str, 54454 Thessaloniki, Greece. Tel.: +30 2310905178; fax: +30 2310905178.
    • ,
  • Fotios Iliadis

      Affiliations

    • 1st Propedeutic Department of Internal Medicine, AHEPA University Hospital of Thessaloniki, Greece
    • ,
  • Nikoleta Angelopoulou

      Affiliations

    • Department of Physical Education and Sports Science, Aristotle University of Thessaloniki, Greece
    • ,
  • Nikolaos Sailer

      Affiliations

    • 1st Department of Internal Medicine, “Hippokratio” General Hospital of Thessaloniki, Greece
    • ,
  • Grigorios Fotiadis

      Affiliations

    • 1st Department of Internal Medicine, “Hippokratio” General Hospital of Thessaloniki, Greece
    • ,
  • Kleon Voliotis

      Affiliations

    • 1st Department of Internal Medicine, “Hippokratio” General Hospital of Thessaloniki, Greece
    • ,
  • Ioulia Vitta

      Affiliations

    • 1st Department of Internal Medicine, “Hippokratio” General Hospital of Thessaloniki, Greece
    • ,
  • Christos D. Liapis

      Affiliations

    • Department of Vascular Surgery, Medical School, University of Athens, Greece
    • ,
  • Miltiadis Alevizos

      Affiliations

    • 1st Propedeutic Department of Internal Medicine, AHEPA University Hospital of Thessaloniki, Greece

Received 7 August 2007 ,Revised 14 December 2007 ,Accepted 27 December 2007.

References 

  1. Alderman M, Aiyer KJ. Uric acid: Role in cardiovascular disease and effects of losartan. Current Medical Research and Opinion. 2004;20:369–379
  2. Binder J, Bailey KR, Seward JB, Squires RW, Kunihiro T, Hensrud DD, et al. Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. American Journal of Hypertension. 2006;19:1019–1024
  3. Blair SN, Kohl HW, Barlow CE, Paffenbarger RS, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality. Journal of the American Medical Association. 1995;273:1093–1098
  4. Bouchard C, Daw EW, Rice T, Perusse L, Gagnon J, Province MA, et al. Familial resemblance for V̇o2max in the sedentary state: the HERITAGE family study. Medicine and Science in Sports and Exercise. 1998;30:252–258
  5. Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, et al. American Heart Association; American Diabetes Association. Primary prevention of cardiovascular diseases in people with diabetes mellitus: A scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care. 2007;30:162–172
  6. Chevion S, Moran DS, Heled Y, Shani Y, Regev G, Abbou B, et al. Plasma antioxidant status and cell injury after severe physical exercise. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:5119–5123
  7. Church TS, Finley CE, Earnest CP, Kampert JB, Gibbons LW, Blair SN. Relative associations of fitness and fatness to fibrinogen, white blood cell count, uric acid and metabolic syndrome. International Journal of Obesity and Related Metabolic Disorders. 2002;26:805–813
  8. Coppola L, Grassia A, Coppola A, Tondi G, Peluso G, Mordente S, et al. Effect of a moderate intensity aerobic program on blood viscosity, platelet aggregation, and fibrinolytic balance in young and middle-aged sedentary subjects. Blood Coagulation & Fibrinolysis. 2004;15:31–37
  9. DeSouza CA, Jones PP, Seals DR. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arteriosclerosis, Thrombosis, and Vascular Biology. 1998;18:362–368
  10. Dunstan DW, Mori TA, Puddey IB, Beilin LJ, Burke V, Morton AR, et al. A randomized control study of the effects of aerobic exercise and dietary fish coagulation and fibrinolytic factors in Type 2 diabetes. Thrombosis and Hemostasis. 1999;81:367–372
  11. Estacio RO, Regensteiner JG, Wolfel EE, Jeffers B, Dickenson M, Schrier RW. The association between diabetic complications and exercise capacity in NIDDM patients. Diabetes Care. 1998;21:291–295
  12. Finaud J, Lac G, Filaire E. Oxidative stress: Relationship with exercise and training. Sports Medicine. 2006;36:327–358
  13. Fogelholm M, Malmberg J, Suni J, Santtila M, Kyrolainen H, Mantysaari M. Waist circumference and BMI are independently associated with the variation of cardio-respiratory and neuromuscular fitness in young adult men. International Journal of Obesity (Lond). 2006;30:962–969
  14. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with Type 2 diabetes and in non-diabetic subjects with and without prior myocardial infarction. New England Journal of Medicine. 1998;339:229–234
  15. Hammett CJ, Prapavessis H, Baldi JC, Varo N, Schoenbeck U, Ameratunga R, et al. Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk. American Heart Journal. 2006;51:367.e7–367.e16
  16. Henry RR. Insulin resistance: From predisposing factor to therapeutic target in Type 2 diabetes. Clinical Therapeutics. 2003;25(Suppl B):B47–B63
  17. Janssen I, Katzmarzyk PT, Ross R, Leon AS, Skinner JS, Rao DC, et al. Fitness alters the associations of BMI and waist circumference with total and abdominal fat. Obesity Research. 2004;12:525–537
  18. Kirk A, Mutrie N, MacIntyre P, Fisher M. Effects of a 12-month physical activity counselling intervention on glycaemic control and on the status of cardiovascular risk factors in people with Type 2 diabetes. Diabetologia. 2004;47:821–832
  19. Kriketos AD, Carey DG, Jenkins AB, Chisholm DJ, Furler SM, Campbell LV. Central fat predicts deterioration of insulin secretion index and fasting glycaemia: 6-year follow-up of subjects at varying risk of Type 2 diabetes mellitus. Diabetic Medicine. 2003;20:294–300
  20. Lau AC, Lo MK, Leung GT, Choi FP, Yam LY, Wasserman K. Altered exercise gas exchange as related to microalbuminuria in Type 2 diabetic patients. Chest. 2004;125:1292–1298
  21. Lazarevic G, Antic S, Vlahovic P, Djordjevic V, Zvezdanovic L, Stefanovic V. Effects of aerobic exercise on microalbuminuria and enzymuria in Type 2 diabetic patients. Renal Failure. 2007;29:199–205
  22. Lehto S, Niskanen L, Ronnemaa T, Laakso M. Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke. 1998;29:635–639
  23. Lindahl B, Nilsson TK, Jansson JH, Asplund K, Hallmans G. Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. Journal of Internal Medicine. 1999;246:105–112
  24. McGavock JM, Mandic S, Muhll IV, Lewanczuk RZ, Quinney HA, Taylor DA, et al. Low cardiorespiratory fitness is associated with elevated C-reactive protein levels in women with Type 2 diabetes. Diabetes Care. 2004;27:320–325
  25. Menke A, Muntner P, Wildman RP, Reynolds K, He J. Measures of adiposity and cardiovascular disease risk factors. Obesity (Silver Spring). 2007;15:785–795
  26. Neil HA, DeMicco DA, Luo D, Betteridge DJ, Colhoun HM, Durrington PN, et al. Analysis of efficacy and safety in patients aged 65–75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS). Diabetes Care. 2006;29:2378–2384
  27. Regensteiner JG, Sippel J, McFarling ET, Wolfel EE, Hiatt WR. Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Medicine and Science in Sports and Exercise. 1995;27:875–881
  28. Schmieder RE, Schrader J, Zidek W, Tebbe U, Paar WD, Bramlage P, et al. Low-grade albuminuria and cardiovascular risk: What is the evidence?. Clinical Research in Cardiology. 2007;96:247–257
  29. Schneider SH, Khachadurian AK, Amorosa LF, Clemow L, Ruderman NB. Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus. Diabetes Care. 1992;15:1800–1810
  30. Shankar A, Klein BE, Nieto FJ, Klein R. Association between serum uric acid level and peripheral arterial disease. Atherosclerosis. 2008;196:749–755
  31. Smith A, Patterson C, Yarnell J, Rumley A, Ben-Shlomo Y, Lowe G. Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study. Circulation. 2005;112:3080–3087
  32. Sobel BE, Schneider DJ. Platelet function, coagulopathy, and impaired fibrinolysis in diabetes. Cardiology Clinics. 2004;22:511–526
  33. Stehouwer CD, Gall MA, Twisk JW, Knudsen E, Emeis JJ, Parving HH. Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in Type 2 diabetes: progressive, interrelated, and independently associated with risk of death. Diabetes. 2002;51:1157–1165
  34. Stewart K. Exercise training and the cardiovascular consequences of type diabetes and hypertension. Journal of the American Medical Association. 2002;288:1622–1631
  35. Taylor HL, Jacobs DR, Schucker B, Knudsen J, Leon AS, Debacker G. A questionnaire for the assessment of leisure time physical activities. Journal of Chronic Diseases. 1978;31:741–755
  36. Ugur-Altun B, Altun A, Tatli E, Tugrul A. Factors related to exercise capacity in middle-aged Type 2 diabetic patients. Diabetes Research and Clinical Practice. 2005;67:130–136
  37. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in Type 2 diabetes: UKPDS 38. British Medical Journal. 1998;317:703–713
  38. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487–1495
  39. Wannamethee SG, Shaper AG, Alberti KG. Physical activity, metabolic factors, and the incidence of coronary heart disease and Type 2 diabetes. Archives of Internal Medicine. 2000;160:2108–2116
  40. Warnick GR, Knopp RH, Fitzpatrick V, Branson L. Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints. Clinical Chemistry. 1990;36:15–19
  41. Wei M, Gibbons LW, Kampert JB, Nichaman MZ, Blair SN. Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with Type 2 diabetes. Annals of Internal Medicine. 2000;18:605–611
  42. Wilmore J, Green J, Stanforth P, Gagnon J, Rankinen T, Leon A, et al. Relationship of changes in maximal and submaximal aerobic fitness to changes in cardiovascular disease and non-insulin dependent diabetes mellitus risk factors with endurance training: The Heritage family study. Metabolism. 2001;50:1255–1263
  43. Womack CJ, Nagelkirk PR, Coughlin AM. Exercise-induced changes in coagulation and fibrinolysis in healthy populations and patients with cardiovascular disease. Sports Medicine. 2003;33:795–807
  44. Wong SL, Katzmarzyk P, Nichaman MZ, Church TS, Blair SN, Ross R. Cardiorespiratory fitness is associated with lower abdominal fat independent of body mass index. Medicine and Science in Sports and Exercise. 2004;36:286–291
  45. Xu Y, Whitmer K. C-reactive protein and cardiovascular disease in people with diabetes: high-sensitivity CRP testing can help assess risk for future cardiovascular disease events in this population. American Journal of Nursing. 2006;106:66–72
  46. Zoppini G, Targher G, Zamboni C, Venturi C, Cacciatori V, Moghetti P, et al. Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with Type 2 diabetes. Nutrition, Metabolism, and Cardiovascular Diseases. 2006;16:543–549

☆ ClinicalTrials.gov Identifier: NCT00306176.

PII: S1056-8727(08)00004-4

doi: 10.1016/j.jdiacomp.2007.12.008

Journal of Diabetes and Its Complications
Volume 23, Issue 3 , Pages 160-166 , May 2009

Article Tools