Journal of Diabetes and Its Complications
Volume 23, Issue 3 , Pages 178-184 , May 2009

Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy

  • Mayumi Higurashi

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    • Division of Clinical Research, Sakura National Hospital, Chiba, Japan
    • The Japanese Association Clinic, Singapore, Singapore
    • Corresponding Author InformationCorresponding author. The Japanese Association Clinic, Singapore, 120 Adam Road, Singapore 289899, Singapore. Tel.: +65 64696488; fax: +65 64671298.
  • ,
  • Yoshiyuki Ohya

      Affiliations

    • Division of Pathology, Sakura National Hospital, Chiba, Japan
  • ,
  • Kensuke Joh

      Affiliations

    • Division of Pathology, Sakura National Hospital, Chiba, Japan
    • Clinical Research Center, National Hospital Organization Chiba-East National Hospital, Chiba, Japan
  • ,
  • Masahiro Muraguchi

      Affiliations

    • Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd., Tokushima, Japan
  • ,
  • Motonobu Nishimura

      Affiliations

    • Division of Clinical Research, Sakura National Hospital, Chiba, Japan
    • Clinical Research Center, National Hospital Organization Chiba-East National Hospital, Chiba, Japan
  • ,
  • Hiroyuki Terawaki

      Affiliations

    • Division of Clinical Research, Sakura National Hospital, Chiba, Japan
  • ,
  • Kazuo Yagui

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
  • ,
  • Naotake Hashimoto

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
  • ,
  • Yasushi Saito

      Affiliations

    • Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
  • ,
  • Kenichi Yamada

      Affiliations

    • Division of Clinical Research, Sakura National Hospital, Chiba, Japan
    • Clinical Research Center, National Hospital Organization Chiba-East National Hospital, Chiba, Japan

Received 17 August 2007 ,Revised 12 November 2007 ,Accepted 7 December 2007.

References 

  1. Baggiolini M, Dewald B, Moser B. Human chemokines. An update. Annual Review of Immunology. 1997;15:675–705
  2. Carr ME. Diabetes mellitus: a hypercoagulable state. Journal of Diabetes and Its Complications. 2001;15:44–54
  3. Chen J, Gall MA, Yokoyama H, Jensen JS, Deckert M, Parving HH. Raised serum sialic acid concentrations in NIDDM patients with and without diabetic nephropathy. Diabetes Care. 1996;19:130–134
  4. Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC, Tesch GH. Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice. Journal of the American Society of Nephrology. 2005;16:1711–1722
  5. Cooper ME. Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet. 1998;352:213–219
  6. Dalla Vestra M, Mussap M, Gallina P, Bruseghin M, Cernigoi AM, Saller A, et al. Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes. Journal of the American Society of Nephrology. 2005;16:S78–S82
  7. Fridovich I. The biology of oxygen radicals. Science. 1978;201:875–880
  8. Furuta T, Saito T, Ootaka T, Soma J, Obara K, Abe K, et al. The role of macrophages in diabetic glomerulosclerosis. American Journal of Kidney Diseases. 1993;21:480–485
  9. Galkina E, Ley K. Leukocyte recruitment and vascular injury in diabetic nephropathy. Journal of the American Society of Nephrology. 2006;17:368–377
  10. Hirata K, Shikata K, Matsuda M, Akiyama K, Sugimoto H, Kushiro M, et al. Increased expression of selectins in kidneys of patients with diabetic nephropathy. Diabetologia. 1998;41:185–192
  11. Ihm CG, Park JK, Hong SP, Lee TW, Cho BS, Kim MJ, et al. A high glucose concentration stimulates the expression of monocyte chemotactic peptide 1 in human mesangial cells. Nephron. 1998;79:33–37
  12. Kelly DJ, Chanty A, Gow RM, Zhang Y, Gilbert RE. Protein kinase C beta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental nephropathy. Journal of the American Society of Nephrology. 2005;16:1654–1660
  13. Mezzano S, Droguett A, Burgos ME, Ardiles LG, Flores CA, Aros CA, et al. Renin–angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney International. 2003;64(Suppl 86):S64–S70
  14. Navarro JF, Mora C. Role of inflammation in diabetic complications. Nephrol Dial Transplant. 2005;20:2601–2604
  15. Navarro JF, Mora C, Macía M, Garcia J. Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus. American Journal of Kidney Diseases. 2003;42:53–61
  16. Navarro JF, Mora C, Rivero A, Gallego E, Chahin J, Macia M, et al. Urinary protein excretion and serum tumor necrosis factor in diabetic patients with advanced renal failure: effects of pentoxifylline administration. American Journal of Kidney Diseases. 1999;33:458–463
  17. Ohmori M, Harada K, Kitoh Y, Nagasaka S, Saito T, Fujimura A. The functions of circulatory polymorphonuclear leukocytes in diabetic patients with and without diabetic triopathy. Life sciences. 2000;66:1861–1870
  18. Olszyna DP, Opal SM, Prins JM, Horn DL, Speelman P, van Devennter SJ, et al. Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-α, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis. The Journal of Infectious Diseases. 2000;182:1731–1737
  19. Omoto S, Nomura S, Shouzu A, Hayakawa T, Shimizu H, Miyake Y, et al. Significance of platelet-derived microparticles and activated platelets in diabetic nephropathy. Nephron. 1999;81:271–277
  20. Power CA, Clemetson JM, Clemetson KJ, Wells TN. Chemokine and chemokine receptor mRNA expression in human platelets. Cytokine. 1995;7:479–482
  21. Romagnani P, Beltrame C, Annunziato F, Lasagni L, Luconi M, Galli G, et al. Role for interactions between IP-10/Mig and CXCR3 in proliferative glomerulonephritis. Journal of the American Society of Nephrology. 1999;10:2518–2526
  22. Romagnani P, Lazzeri E, Lasagni L, Mavilla C, Beltrame C, Francalanci M, et al. IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxide. Journal of the American Society of Nephrology. 2002;13:53–64
  23. Schlöndorff D, Nelson PJ, Luckow B, Banas B. Chemokines and renal disease. Kidney International. 1997;51:610–621
  24. Schmid H, Boucherot A, Yasuda Y, Henger A, Brunner B, Eichinger F, et al. Modular activation of nuclear factor-κB transcriptional programs in human diabetic nephropathy. Diabetes. 2006;55:2993–3003
  25. Schmouder RL, Strieter RM, Walz A, Kunkel SL. Epithelial-derived neutrophil-activating factor-78 production in human renal tubule epithelial cells and in renal allograft rejection. Transplantation. 1995;59:118–124
  26. Schreiner GF. The role of the macrophage in glomerular injury. Seminars in Nephrology. 1991;11:268–275
  27. Schwedler S, Schinzel R, Vaith P, Wanner C. Inflammation and advanced glycation end products in uremia: Simple coexistence, potentiation or causal relationship?. Kidney International. 2001;59(Suppl 78):S32–S36
  28. Segerer S, Nelson PJ, Schlöndorff D. Chemokines, chemokine receptors, and renal disease: From basic science to pathophysiologic and therapeutic studies. Journal of the American Society of Nephrology. 2000;11:152–176
  29. Segerer S, Banas B, Wöornle M, Schmid H, Cohen CD, Kretzler M, et al. CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. The American Journal of Pathology. 2004;164:635–649
  30. Takahashi T, Hato F, Yamane T, Inaba M, Okuno Y, Nishizawa Y, et al. Increased spontaneous adherence of neutrophils from type 2 diabetic patients with overt proteinuria. Diabetes Care. 2000;23:417–418
  31. Tuttle KR. Linking metabolism and immunology: diabetic nephropathy is an inflammatory disease. Journal of the American Society of Nephrology. 2005;16:1537–1538
  32. Tashiro K, Koyanagi I, Saitoh A, Shimizu A, Shike T, Ishiguro C, et al. Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and Interleukin-8 (IL-8), and renal injuries in patients with type 2 diabetic nephropathy. Journal of Clinical Laboratory Analysis. 2002;16:1–4
  33. Utimura R, Fujihara CK, Mattar AL, Malheiros DM, Noronha IL, Zatz R. Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes. Kidney International. 2003;63:209–216
  34. Walz A, Burgener R, Car B, Baggiolini M, Kunkel SL, Strieter RM. Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. The Journal of Experimental Medicine. 1991;174:1355–1362
  35. Wong CK, Ho AW, Tong PC, Yeung CY, Kong AP, Lun SW, et al. Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy. Clinical and Experimental Immunology. 2007;149:123–131
  36. Young BA, Johnson RJ, Alpers CE, Eng E, Gordon K, Floege J, et al. Cellular events in the evolution of experimental diabetic nephropathy. Kidney International. 1995;47:935–944

 This work was supported by a Health and Labour Science Research Grant for Clinical Research in Evidenced Based Medicine (0209001) from the Ministry of Health, Labour and Welfare of Japan. A portion of this study was presented by Mayumi Higurashi in the poster presentation entitled “Involvement of Activated Macrophages in the Development of Diabetic Nephropathy” at the Renal Week 2003 Meeting, San Diego, CA, USA, November 14–17, 2003.

PII: S1056-8727(07)00147-X

doi: 10.1016/j.jdiacomp.2007.12.001

Journal of Diabetes and Its Complications
Volume 23, Issue 3 , Pages 178-184 , May 2009