Journal of Diabetes and Its Complications
Volume 23, Issue 2 , Pages 124-129 , March 2009

Rosiglitazone protects diabetic rats against kidney disease through the suppression of renal moncyte chemoattractant protein-1 expression

  • Mao Zheng

      Affiliations

    • Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, Anhui Province of China
  • ,
  • Shandong Ye

      Affiliations

    • Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, Anhui Province of China
    • Corresponding Author InformationCorresponding author. Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medica, Hefei, Anhui Province of China 2300001, China. Tel.: +86 551 2283292; fax: +86 551 2283292.
  • ,
  • Zhimin Zhai

      Affiliations

    • Endocrinological Laboratory of Anhui Provincial Hospital, Anhui Provincial Hospital affiliated to Anhui Medical University, Anhui Medical University, Hefei, Anhui Province of China
  • ,
  • Yan Chen

      Affiliations

    • Endocrinological Laboratory of Anhui Provincial Hospital, Anhui Provincial Hospital affiliated to Anhui Medical University, Anhui Medical University, Hefei, Anhui Province of China
  • ,
  • Xiucai Li

      Affiliations

    • Endocrinological Laboratory of Anhui Provincial Hospital, Anhui Provincial Hospital affiliated to Anhui Medical University, Anhui Medical University, Hefei, Anhui Province of China
  • ,
  • Guangwei Yang

      Affiliations

    • Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, Anhui Province of China
  • ,
  • Aihong Fan

      Affiliations

    • Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, Anhui Province of China
  • ,
  • Yingxin Wang

      Affiliations

    • Department of Pharmacology, Anhui Medical College, Hefei, Anhui Province of China

Received 1 May 2007 ,Revised 4 September 2007 ,Accepted 9 November 2007.

Reference 

  1. Agarwal R. Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathy. American Journal of Physiology Renal Physiology. 2006;290:F600–F605
  2. Bakris G, Viberti G, Weston WM, Heise M, Porter LE, Freed MI. Rosiglitazone reduces urinary albumin excretion in type II diabetes. Journal of Human Hypertension. 2003;17:7–12
  3. Banba N, Nakamura T, Matsumura M, Kuroda H, Hattori Y, Kasai K. Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney International. 2000;58:684–690
  4. Bohle A, Bader R, Grund KE, Mackensen S, Neunhoeffer J. Serum creatinine concentration and renal interstitial volume. Analysis of correlations in endocapillary (acute) glomerulonephritis and in moderately severe mesangioproliferative glomerulonephritis. Virchows Archive A Pathological Anatomy and Histology. 1977;3751:87–96
  5. Buckingham RE. Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection. Hepatology Research. 2005;33:167–170
  6. Chappey O, Dosquet C, Wautier MP, Wautier JL. Advanced glycation end products, oxidant stress and vascular lesions. European Journal of Clinical Investigation. 1997;27:97–108
  7. Cooper ME. Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet. 1998;352:213–219
  8. Dalla Vestra M, Mussap M, Gallina P, Bruseghin M, Cernigoi AM, Saller A, et al. Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes. Journal of the American Society of Nephrology. 2005;16(Suppl 1):S78–S82
  9. Egido J. Chemokines, chemokine receptors and renal disease. Kidney International. 1999;56:347–348
  10. Game BA, He L, Jarido V, Nareika A, Jaffa AA, Lopes-Virella MF, et al. Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice. Atherosclerosis. 2007;192:85–91
  11. Gruden G, Setti G, Hayward A, Sugden D, Duggan S, Burt D, et al. Mechanical stretch induces monocyte chemoattractant activity via an NF-kappaB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: Inhibition by rosiglitazone. Journal of the American Society of Nephrology. 2005;16:688–696
  12. Han SY, Kim CH, Kim HS, Jee YH, Song HK, Lee MH, et al. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Journal of the American Society of Nephrology. 2006;17:1362–1372
  13. Hisada Y, Sugaya T, Yamanouchi M, Uchida H, Fujimura H, Sakurai H, et al. Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice. Journal of Clinical Investigation. 1999;103:627–635
  14. Isshiki K, Haneda M, Koya D, Maeda S, Sugimoto T, Kikkawa R. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. Diabetes. 2000;49:1022–1032
  15. Kikuchi Y, Imakiire T, Yamada M, Saigusa T, Hyodo T, Hyodo N, et al. Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic rats. Nephrology Dialysis Transplantation. 2005;20:1573–1581
  16. Lee S, Kim W, Kang KP, Moon SO, Sung MJ, Kim DH, et al. Agonist of peroxisome proliferator-activated receptor-gamma, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model. Nephrology Dialysis Transplantation. 2005;20:1057–1065
  17. Luster AD. Chemokines—chemotactic cytokines that mediate inflammation. New England Journal of Medicine. 1998;338:436–445
  18. Morrissey JJ, Klahr S. Differential effects of ACE and AT1 receptor inhibition on chemoattractant and adhesion molecule synthesis. American Journal of Physiology. 1998;274:F580–F586
  19. Panchapakesan U, Pollock CA, Chen XM. The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells. American Journal of Physiology Renal Physiology. 2004;287:F528–F534
  20. Pistrosch F, Herbrig K, Kindel B, Passauer J, Fischer S, Gross P. Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients. Diabetes. 2005;54:2206–2211
  21. Ruiz-Ortega M, Bustos C, Hernández-Presa MA, Lorenzo O, Plaza JJ, Egido J. Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesis. Journal of Immunology. 1998;161:430–439
  22. Sarafidis PA, Lasaridis AN, Nilsson PM, Hitoglou-Makedou AD, Pagkalos EM, Yovos JG, et al. The effect of rosiglitazone on urine albumin excretion in patients with type 2 diabetes mellitus and hypertension. American Journal of Hypertension. 2005;18:227–234
  23. Tanimoto M, Fan Q, Gohda T, Shike T, Makita Y, Tomino Y. Effect of pioglitazone on the early stage of type 2 diabetic nephropathy in KK/Ta mice. Metabolism. 2004;53:1473–1479
  24. Viedt C, Dechend R, Fei J, Hänsch GM, Kreuzer J, Orth SR. MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1. Journal of the American Society of Nephrology. 2002;13:1534–1547
  25. Wada T, Furuichi K, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, et al. Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy. Kidney International. 2000;58:1492–1499
  26. Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, et al. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. Journal of Experimental Medicine. 1988;167:570–581
  27. Yamashita H, Nagai Y, Takamura T, Nohara E, Kobayashi K. Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat. Metabolism. 2002;51:403–408
  28. Zafiriou S, Stanners SR, Polhill TS, Poronnik P, Pollock CA. Pioglitazone increases renal tubular cell albumin uptake but limits proinflammatory and fibrotic responses. Kidney International. 2004;65:1647–1653

PII: S1056-8727(07)00146-8

doi: 10.1016/j.jdiacomp.2007.11.012

Journal of Diabetes and Its Complications
Volume 23, Issue 2 , Pages 124-129 , March 2009