The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats

Lin, Yang; Ye, Shandong; Chen, Yan; Li, Xiucai; Yang, Guang-wei; Fan, Aihong; Wang, Yingxin

doi:10.1016/j.jdiacomp.2007.09.003

« Previous Next »Journal of Diabetes and Its Complications
Volume 23, Issue 3 , Pages 214-218, May 2009

The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats

Yang Lin
- Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, 230001, China
Shandong Ye
- Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, 230001, China
- Corresponding author. Tel.: +86 551 2283301; fax: +86 551 2283292.
Yan Chen
- Endocrinological Laboratory of Anhui Provincial Hospital, Hefei, 230001, China
Xiucai Li
- Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, 230001, China
Guang-wei Yang
- Department of Endocrinology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, 230001, China
Aihong Fan
- Endocrinological Laboratory of Anhui Provincial Hospital, Hefei, 230001, China
Yingxin Wang
- Department of Pharmacology, Anhui Medical College, Hefei, China

Received 28 July 2007; accepted 6 September 2007. published online 14 March 2008.

Abstract

Objective

This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats.

Methods

Twenty-four Wistar rats were randomly assigned to a normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C were treated with simvastatin (20 mg kg⁻¹ day⁻¹) 1 week after the establishment of the diabetic model. Groups A and B were treated with corresponding sodium chloride. Peripheral blood glucose was tested weekly; serum MCP-1, ICAM-1, and HbA1c levels were tested at the eighth week.

Results

At the second, fourth, and eighth week, peripheral blood glucose levels in Group B were similar to those of Group C, which were much higher than those of Group A. Serum MCP-1 and ICAM-1 levels in Groups B and C were higher than those of Group A (P<.01), and serum MCP-1 and ICAM-1 levels in Group C were lower than those of Group B (P<.01); HbA1c was not significantly different between Group C and Group B.