Journal of Diabetes and Its Complications
Volume 20, Issue 3 , Pages 137-144 , May 2006

Comparison of type 1, type 2, and atypical ketosis-prone diabetes at 4 years of diabetes duration

  • María A. Ramos-Román

      Affiliations

    • Department of Internal Medicine at the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8858, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 214 648 2017; fax: +1 214 648 4854
    • ,
  • Antonio Piñero-Piloña

      Affiliations

    • Department of Internal Medicine at the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8858, USA
    • ,
  • Beverley Adams-Huet

      Affiliations

    • Center for Biostatistics and Clinical Sciences at the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8858, USA
    • ,
  • Philip Raskin

      Affiliations

    • Department of Internal Medicine at the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8858, USA

Received 22 December 2005 ,Accepted 11 January 2006.

References 

  1. Banerji MA, Chaiken RL, Huey H, Tuomi T, Norin AJ, Mackay IR, et al. GAD antibody negative NIDDM in adult black subjects with diabetic ketoacidosis and increased frequency of Human Leukocyte Antigen DR3 and DR4. Diabetes. 1994;43:741–745
  2. Banerji MA, Chaiken RL, Lebovitz HE. Long-term normoglycemic remission in black newly diagnosed NIDDM subjects. Diabetes. 1996;45:337–341
  3. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. American Journal of Physiology. 1979;237:E214–E223
  4. El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death. Endocrinology. 2003;144:4154–4163
  5. Gerich JE, Tsalikian E, Lorenzi M, Karam JH, Bier DM. Plasma glucagon and alanine responses to acute insulin deficiency in man. Journal of Clinical Endocrinology and Metabolism. 1975;40:526–529
  6. Gosmanov AR, Umpierrez GE, Karabell AH, Cuervo R, Thomason DB. Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes. American Journal of Physiology, Endocrinology, and Metabolism. 2004;287:E8–E15
  7. Kelley DE, Mandarino LJ. Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. Journal of Clinical Investigation. 1990;86:1999–2007
  8. Kelley DE, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: A reexamination. Diabetes. 2000;49:677–683
  9. Kitabchi AE, Umpierrez GE. Changes in serum leptin in lean and obese subjects with acute hyperglycemic crises. Journal of Clinical Endocrinology and Metabolism. 2003;88:2593–2596
  10. Kosaka K, Kuzuya T, Akanuma Y, Hagura R. Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment. Diabetologia. 1980;18:23–28
  11. Koskinen P, Viikari J, Irjala K, Kaihola HL, Seppälä P. C-peptide determination in the choice of treatment in diabetes mellitus. Scandinavian Journal of Clinical and Laboratory Investigation. 1985;45:589–597
  12. Lusk G. Animal calorimetry. Analysis of the oxidation of mixtures of carbohydrate and fat. Journal of Biological Chemistry. 1924;59:41–42
  13. Maldonado M, Hampe CS, Gaur LK, D'Amico S, Iyer D, Hammerle LP, et al. Ketosis-prone diabetes: Dissection of a heterogeneous syndrome using an immunogenetic and β-cell functional classification, prospective analysis, and clinical outcomes. Journal of Clinical Endocrinology and Metabolism. 2003;88:5090–5098
  14. Marena S, Montegrosso G, De Michieli F, Pisu E, Pagano G. Comparison of the metabolic effects of mixed meal and standard oral glucose tolerance test on glucose, insulin and C-peptide response in healthy, impaired glucose tolerance, mild and severe non-insulin-dependent diabetic subjects. Acta Diabetologica. 1992;29:29–33
  15. Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, et al. Pax4 gene variations predispose to ketosis-prone diabetes. Human Molecular Genetics. 2004;13:3151–3159
  16. Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, et al. Ketosis-prone type 2 diabetes in patients of Sub-Saharan African origin. Diabetes. 2004;53:645–653
  17. Mauvais-Jarvis F, Sobngwi E, Riveline JP, Guillausseau PJ, Charpentier G, Vexiau P, et al. Genetic analysis of the transcription factors Ngn3, Nkx2.2 and Pax4 in ketosis-prone diabetes. Diabetes (Abstract). 2004;A513–A514
  18. O'Rahilly S, Barroso I, Wareham NJ. Genetic factors in type 2 diabetes: The end of the beginning?. Science. 2005;307:370–373
  19. Piñero-Piloña A, Litonjua P, Avilés-Santa L, Raskin P. Idiopathic type 1 diabetes in Dallas, Texas. Diabetes Care. 2001;24:1014–1018
  20. Piñero-Piloña A, Raskin P. Idiopathic type 1 diabetes. Journal of Diabetes and Its Complications. 2001;15:328–335
  21. Pitteloud N, Philippe J. Characteristics of Caucasian type 2 diabetic patients during ketoacidosis and at follow-up. Schweizerische Medizinische Wochenschrift. 2000;130:576–582
  22. Prentki M, Joly E, El-Assaad W, Roduit R. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity. Diabetes. 2002;51(Suppl. 3):S405–S413
  23. Rasouli N, Elbein SC. Improved glycemic control in subjects with atypical diabetes results from restored insulin secretion, but not improved insulin sensitivity. Journal of Clinical Endocrinology and Metabolism. 2004;89:6331–6335
  24. Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. Journal of Biological Chemistry. 2004;279:42351–42354
  25. Shimajiri Y, Sanke T, Furuta H, Hanabusa T, Nakagawa T, Fujitani Y, et al. A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese. Diabetes. 2001;50:2864–2869
  26. Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, et al. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. Journal of Clinical Endocrinology and Metabolism. 2005;90:4446–4451
  27. Sobngwi E, Mauvais-Jarvis F, Vexiau P, Mbanya JC, Gautier JF. Diabetes in Africans Part 2: Ketosis-prone atypical diabetes mellitus. Diabetes Metab. 2002;28:5–12
  28. Tan KC, Mackay IR, Zimmet PZ, Hawkins BR, Lam KS. Metabolic and immunologic features of Chinese patients with atypical diabetes mellitus. Diabetes Care. 2000;23:335–338
  29. Tanaka K, Moriya T, Kanamori A, Yajima Y. Analysis and long-term follow up of ketosis-onset Japanese NIDDM patients. Diabetes Research and Clinical Practice. 1999;44:137–146
  30. Tappy L, Owen OE, Boden G. Effect of hyperinsulinemia on urea pool size and substrate oxidation rates. Diabetes. 1988;37:1212–1216
  31. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus . Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183–1197
  32. Thiebaud D, Jacot E, DeFronzo RA, Maeder E, Jequier E, Felber JP. The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes. 1982;31:957–963
  33. UK Prospective Diabetes Study Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–853
  34. Umpierrez GE, Casals MM, Gebhart SS, Mixon PS, Clark WS, Phillips LS. Diabetic ketoacidosis in obese African-Americans. Diabetes. 1995;44:790–795
  35. Umpierrez GE, Clark WS, Steen MT. Sulfonylurea treatment prevents recurrence of hyperglycemia in obese African-American patients with a history of hyperglycemic crises. Diabetes Care. 1997;20:479–483
  36. Unger RH. The hyperleptinemia of obesity: Regulator of caloric surpluses. Cell. 2004;117:145–146
  37. Unger RH, Orci L. Diseases of liporegulation: New perspective on obesity and related disorders. FASEB Journal. 2001;15:312–321
  38. Winter WE, Maclaren NK, Riley WJ, Clarke DW, Kappy MS, Spillar RP. Maturity-onset diabetes of youth in Black Americans. New England Journal of Medicine. 1987;316:285–291
  39. Wohl P, Wohl P, Girman P, Pelikánová T. Inflexibility of energy substrate oxidation in type 1 diabetic patients. Metabolism. 2004;53:655–659

☆ This study was supported by USPHS grant M01-RR000633 from NIH-NCRR-CR to the General Clinical Research Center at UT Southwestern Medical Center at Dallas, TX, USA, and training grant 5 T32 DK07307.

PII: S1056-8727(06)00009-2

doi: 10.1016/j.jdiacomp.2006.01.005

Journal of Diabetes and Its Complications
Volume 20, Issue 3 , Pages 137-144 , May 2006

Article Tools

* Image Usage & Resolution