Journal of Diabetes and Its Complications
Volume 20, Issue 2 , Pages 88-97 , March 2006

QT dispersion: Comparison between participants with Type 1 and 2 diabetes and association with microalbuminuria in diabetes

  • Michael Psallas

      Affiliations

    • 1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece
    • ,
  • Nicholas Tentolouris

      Affiliations

    • 1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece
    • Corresponding Author InformationCorresponding author. 33 Lakonias Street, 115 23 Athens, Greece. Tel.: +30 210 745 6261; fax: +30 210 779 1839.
    • ,
  • Dimitrios Papadogiannis

      Affiliations

    • 1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece
    • ,
  • Dimitrios Doulgerakis

      Affiliations

    • 1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece
    • ,
  • Alexandros Kokkinos

      Affiliations

    • 1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece
    • ,
  • Dennis V. Cokkinos

      Affiliations

    • 1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
    • ,
  • Nicholas Katsilambros

      Affiliations

    • 1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, Athens, Greece

Received 7 July 2004 ,Accepted 30 May 2005.

References 

  1. Arildsen H, May O, Christiansen EH, Damsgaard EM. Increased QT dispersion in patients with insulin depended diabetes mellitus. Int J Cardiol. 1999;71:235–242
  2. Aytemir K, Aksoyek S, Ozer N, Gurlek A, Oto A. QT dispersion and autonomic nervous system function in patients with type 1 diabetes. Int J Cardiol. 1998;65:45–50
  3. Bazett HC. An analysis of the time relations of the electrocardiogram. Heart. 1920;7:353–370
  4. Bednar MM, Harrigan EP, Anziano RJ, Camm AJ, Ruskin JN. The QT interval. Prog Cardiovasc Dis. 2001;43(Suppl. 1):1–45
  5. Bellavere F, Ferri M, Guarini L, Bax G, Piccoli A, Cardone C, et al. Prolonged QT period in diabetic autonomic neuropathy; A possible role in sudden cardiac death. Br Heart J. 1987;59:379–383
  6. Berntson GG, Bigger JT, Eckberg DL, Grossman P, Kaufmann PG, Malik M, et al. Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology. 1997;34:623–648
  7. Brooksby P, Batin PD, Nolan J, Lindsay SJ, Andrews R, Mullen M, et al. The relationship between QT intervals and mortality in ambulant patients with chronic heart failure. The United Kingdom Heart Failure Evaluation and Assessment Risk Trial (UK-Heart). Eur Heart J. 1999;20:1335–1341
  8. Christensen PK, Gall MA, Major-Pedersen A. QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin dependent diabetes. J Clin Lab Invest. 2000;60:323–332
  9. Consensus Statement. American Diabetes Association. Report and Recommendations of the San Antonio Conference on Diabetic Neuropathy. Diabetes. 1988;37:1000–1004
  10. Day CP, McComb JM, Campbell RW. QT dispersion: An indication of arrhythmia risk in patients with long QT intervals. Br Heart J. 1990;63:342–344
  11. Dell'omo G, Giorgi D, Di Bello V, Mariani M, Pedrinelli R. Blood pressure independent association of microalbuminuria and left ventricular hypertrophy in hypertensive men. J Intern Med. 2003;254:76–84
  12. Elming H, Holm E, Jun L, Torp-Pedersen C, Kober L, Kircshoff M, et al. The prognostic value of QT interval and QT interval dispersion in all-cause and cardiac mortality in a population of Danish citizens. Eur Heart J. 1998;19:1391–1400
  13. Ewing DJ, Boland O, Nielsen JMM, Cho CG, Clarke BF. Autonomic neuropathy. QT interval lengthening, and unexpected deaths in male diabetic patients. Diabetologia. 1991;34:182–185
  14. Ewing DJ, Campbell IW, Clarke BF. The natural history of diabetic autonomic neuropathy. QJM. 1980;49:95–108
  15. Ewing DJ, Martyn CN, Young RJ, Clarke BF. The value of cardiovascular autonomic function tests: 10 year experience in diabetes. Diabetes Care. 1985;8:491–498
  16. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preperative ultracentrifuge. Clin Chem. 1972;18:499–502
  17. Gerritsen J, Dekker JM, TenVoorde BJ, Kostense PJ, Heine RJ, Bouter LM, et al. Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: The Hoorn Study. Diabetes Care. 2001;24:1793–1798
  18. Gonzalez-Juanatey JR, Garcia-Acuna JM, Pose A, et al. Reduction of QT and QTc dispersion during long-term treatment of systemic hypertension with enalapril. Am J Cardiol. 1998;81:170–174
  19. Han J, Moe GK. Non-uniform recovery of excitability in ventricular muscle. Circ Res. 1996;14:44–52
  20. Howorka K, Pumprla J, Haber P, Koller-Strametz J, Mondrzyk J, Schabmann A. Effects of physical training on heart rate variability in diabetic patients with various degrees of cardiovascular autonomic neuropathy. Cardiovasc Res. 1997;34:206–214
  21. Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure . The sixth report of the joint National Committee on Prevention, Detection, Evaluation and Treatment of high blood pressure (JNC VI). Arch Intern Med. 1997;157:2413–2446
  22. Karpanou EA, Vyssoulis GP, Psichogios A, Malakou A, Kyrozi EA, Cokkinos DV, et al. Regression of left ventricular hypertrophy results in improvement of QT dispersion in patients with hypertension. Am Heart J. 1998;136:765–768
  23. Kautzner J, Yi G, Camm AJ, Malik M. Short- and long-term reproducibility of QT, QTc and QT dispersion measurement in healthy subjects. Pacing Electrophysiol. 1994;17:928–937
  24. Kuo CS, Munakata K, Reddy CP, Surawicz B. Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations. Circulation. 1983;67:1356–1367
  25. Lie JE, Robbins DC, Palmieri V, Bella JN, Roman MJ, Fabsitz R, et al. Association of albuminuria with systolic and diastolic left ventricular dysfunction in type 2 diabetes. The Strong Heart Study. J Am Coll Cardiol. 2003;41:2022–2028
  26. Lim PO, Nys M, Naas AA, Struthers AD, Osbakken M, MacDonald TM. Irbesartan reduces QT dispersion in hypertensive individuals. Hypertension. 1999;33:713–718
  27. Lubinski A, Lewicka-Nowak E, Kempa M, Baczynska AM, Romanowska I, Swiatecka G. New insights into repolarization abnormalities in patients with congenital long QT syndrome. The increased transmural dispersion of repolarization. Pacing Clin Electrophysiol. 1998;21:172–175
  28. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  29. Naas AAO, Davidson NC, Thompson C, Cummings F, Ogston SA, Jung RT, et al. QT and QTc dispersion are accurate predictors of cardiac death in newly diagnosed non-insulin dependent diabetes: Cohort study. BMJ. 1998;316:745
  30. Palmieri V, Tracy RP, Roman MJ, Liu JE, Best LG, Bella JN, et al. Relation of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes. Diabetes Care. 2003;26:2764–2769
  31. Rana BS, Band MM, Ogston S, Morris AD, Pringle SD, Struthers AD. Relation of QT interval dispersion to the number of different cardiac abnormalities in diabetes mellitus. Am J Cardiol. 2002;90:483–487
  32. Rossing P, Breum L, Major-Pedersen A, Sato A, Winding H, Pietersen A, et al. Prolonged QTc interval predicts mortality in patients with type 1 diabetes mellitus. Diabet Med. 2001;18:199–205
  33. Rutter MK, Viswanath S, McComb JM, Kesteven P, Marshall SM. QT prolongation in patients with type 2 diabetes and microalbuminuria. Clin Auton Res. 2002;12:366–372
  34. Sahu P, Lim PO, Rana BS, Struthers AD. QT dispersion in medicine: Electrophysiological Holy Grail or fool's gold?. QJM. 2000;93:425–431
  35. Sawicki PT, Kiwitt S, Bender R, Berger M. The value of QT interval dispersion for identification of total mortality risk in non-insulin-dependent diabetes mellitus. J Intern Med. 1998;243:49–56
  36. Shimakaburo M, Chibana T, Yoshida H, Nagamine F, Komiya I, Takasu N. Increased QT dispersion and cardiac adrenergic dysinnervation in diabetic patients with autonomic neuropathy. Am J Cardiol. 1996;78:1057–1059
  37. Takebayashi K, Sugita R, Tayama K, Aso Y, Takemura Y, Inukai T. The connection between QT dispersion and autonomic neuropathy in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes. 2003;111:351–357
  38. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology . Heart rate variability. Standards of measurements, physiological interpretation, and clinical use. Eur Heart J. 1996;17:354–381
  39. Tentolouris N, Katsilambros N, Papazachos G, Papadogiannis D, Linos A, Stamboulis E, et al. Corrected QT interval in relation to the severity of the diabetic autonomic neuropathy. Eur J. 1997;27:1049–1054
  40. The expert committee on the diagnosis and classification of diabetes mellitus . Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 1997;20:1183–1197
  41. Veglio M, Giunti S, Stevens LK, Fuller JH, Perin PC. EURODIAB IDDM Complications Study Group. Prevalence of Q–T interval dispersion in type 1 diabetes and its relation with cardiac ischemia: The EURODIAB IDDM Complications Study Group. Diabetes Care. 2002;25:702–707
  42. Veglio M, Sivieri R, Chinaglia A, Scaglione L, Cavallo-Perin P. QT interval prolongation and mortality in type 1 diabetic patients. Diabetes Care. 2000;23:1381–1383
  43. Wolk R, Mazurek T, Lusawa W, Wasek W, Rezler J. Left ventricular hypertrophy increases transepicardial dispersion of repolarization in hypertensive patients: A differential effect on QTpeak and QTend dispersion. Eur I Clin Invest. 2001;31:563–569
  44. Wolk R, Stec S, Kulakowski P. Extrasystolic beats affect transmural electrical dispersion during programmed electrical stimulation. Eur J Clin Invest. 2001;4:293–301
  45. Wong KY, Mc Walter RS, Douglas D, Fraser H, Ogston S, Sruthers A. Long QTc predicts future cardiac death in stroke survivors. Heart. 2003;89:377–381

PII: S1056-8727(05)00058-9

doi: 10.1016/j.jdiacomp.2005.05.012

Journal of Diabetes and Its Complications
Volume 20, Issue 2 , Pages 88-97 , March 2006

Article Tools