Journal of Diabetes and Its Complications
Volume 19, Issue 6 , Pages 347-355 , November 2005

High serum TNF-α level in Type 2 diabetic patients with microangiopathy is associated with eNOS down-regulation and apoptosis in endothelial cells

  • Naoki Makino

      Affiliations

    • Section of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 977 27 1681; fax: +81 977 27 1682.
    • ,
  • Toyoki Maeda

      Affiliations

    • Section of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838, Japan
    • ,
  • Masahiro Sugano

      Affiliations

    • Section of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838, Japan
    • ,
  • Shinji Satoh

      Affiliations

    • Section of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838, Japan
    • ,
  • Reiko Watanabe

      Affiliations

    • Abe Medical Clinic, Beppu, Japan
    • ,
  • Nobuyuki Abe

      Affiliations

    • Abe Medical Clinic, Beppu, Japan

Received 12 January 2005 ,Revised 15 March 2005 ,Accepted 14 April 2005.

References 

  1. Bachetti T, Comini L, Agnoletti L, Pedersini P, Gaia G, Cargoni A, et al. Effects of chronic noradrenaline on the nitric oxide pathway in human endothelial cells. Basic Research in Cardiology. 1998;93:250–256
  2. Beisswenger PJ, Makita Z, Curphey TJ, et al. Formation of immunochemical advanced glycosylation end-products precedes and correlates with early manifestations of renal and retinal disease in diabetes. Diabetes. 1995;44:824–829
  3. Bemelmans MHA, van Tis LJH, Buurman WA. Tumor necrosis factor: Function, release and clearance. Critical Reviews in Immunology. 1996;16:1–16
  4. Blakesley VA. The role of growth factors in the pathogenesis of diabetic microvascular complications. In:  LeRoith D,  Taylor SI,  Olefsky JM editor. Diabetes mellitus: A fundamental and clinical text. Vol. 2:Philadelphia: Lippincott; 2000;p. 1000–1008
  5. Celermajer DS. Endothelial dysfunction: Does it matter? Is it reversible?. Journal of the American College of Cardiology. 1997;30:325–333
  6. DeMeyer GRY, Herman AG. Vascular endothelial dysfunction. Progress in Cardiovascular Disease. 1997;39:325–342
  7. Fard A, Tuck CH, Donis JA, Sciacca R, Tullio MRD, Wu HD, et al. Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:2039–2044
  8. Febbraio MA, Steensberg A, Starkie RL, McConell GK, Kingwell BA. Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism. 2003;52:939–944
  9. Flowers MA, Wang Y, Stewart RJ, Patel B, Marsden PA. Reciprocal regulation of endothelin-1 and endothelial constitutive NOS in proliferating endothelial cells. American Journal of Physiology. 1995;269:H1988–H1997
  10. Folkman J, Shing Y. Angiogenesis. Journal of Biological Chemistry. 1992;267:10931–10934
  11. Guo DQ, Wu LW, Dunbar JD, Ozes ON, Mayo LD, Kessler KM, et al. Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell proliferation. Journal of Biological Chemistry. 2000;275:11216–11221
  12. Ho FM, Liu SHCS, Huang PJ, Lin-Shiau SY. High glucose induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH2-terminal kinase and Caspase-3. Circulation. 2000;101(Jun):2618–2624
  13. Kulseng B, Vatten L, Espevik T. Soluble tumor necrosis factor receptors in sera from patients with insulin-dependent diabetes mellitus: Relations to duration and complications of disease. Acta Diabetologica. 1999;36:99–105
  14. Limb GA, Soomro H, Janikoun S, Hollifield RD, Shilling J. Evidence for control of tumor necrosis factor-a (TNF-a) activity by TNF receptors in patients with proliferative diabetic retinopathy. Clinical and Experimental Immunology. 1999;115:409–414
  15. Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, et al. Impaired nitric oxide synthase pathway in diabetes mellitus: Role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation. 2002;106:987–992
  16. Mantovani A, Bussolino F, Dejana E. Cytokine regulation of endothelial cell function. FASEB Journal. 1992;6:2591–2599
  17. McQuillan LP, Leung GK, Marsden PA, Kostyk SK, Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. American Journal of Physiology. 1994, Nov;267:H1921–H1927
  18. Miyazaki H, Matsuoka H, Cooke JP, et al. Endogenous nitric oxide synthase inhibitor: A novel marker of atherosclerosis. Circulation. 1999;99:1141–1146
  19. Moncada S, Higgs A. The arginine–nitric oxide pathway. New England Journal of Medicine. 1993;27:2002–2011
  20. O'Driscoll G, Green D, Maiorana A, Stanton K, Colreavy F, Taylor R. Improvement in endothelial function by ACE inhibition in non-insulin-dependent diabetes mellitus. Journal of the American College of Cardiology. 1999;33:1506–1511
  21. Pankewycz OG, Guan J-X, Benedict JF. Cytokines as mediators of autoimmune diabetes and diabetic complications. Endocrine Reviews. 1995;16:164–176
  22. Patterson C, Perrella MA, Endege WO, Yoshizumi M, Lee ME, Haber E. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. Journal of Clinical Investigation. 1996;98:490–496
  23. Rauchhaus M, Doehner W, Francis DP, et al. Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation. 2000;102:3060–3067
  24. Rosenkranz-Weiss P, Sessa WC, Milstien S, Kaufman S, Watson CA, Pober JS. Regulation of nitric oxide synthesis by proinflammatory cytokines in umbilical vein endothelial cells. Journal of Clinical Investigation. 1994;93:2236–2243
  25. Sampson MJ, Davies IR, Brow JC, Ivory K, Hughes DA. Monocyte and neutrophil adhesion molecule expression during acute hyperglycemia and after antioxidant treatment in type 2 diabetes and control patients. Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1187–1193
  26. Schächinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899–1906
  27. Spyridopoulos I, Brogi E, Kearney M, Sullivan AB, Cetrulo C, Isner JM, et al. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: Balance between growth and death signals. Journal of Molecular and Cellular Biology. 1997;29:1321–1330
  28. Stehouwer CAD, Schaper NC. The pathogenesis of vascular complications of diabetes mellitus: One voice or many?. European Journal of Clinical Investigation. 1996;26:535–543
  29. Sugano M, Koyanagi M, Tsuchida K, Hata T, Makino N. In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction. FASEB Journal. 2002;16:1421–1422
  30. Sugano M, Tsuchida K, Makino N. High density lipoprotein protect endothelial cells from tumor necrosis factor-a induced apoptosis. Biochem and Biophysical Research Communication. 2000;272:872–876
  31. Sugano M, Tsuchida K, Tomita H, Makino N. Increased proliferation of endothelial cells with overexpression of soluble TNF-a receptor I gene. Atherosclerosis. 2002;162:77–84
  32. Tracey KJ, Cerami A. Tumor necrosis factor: A pleiotropic cytokine and therapeutic target. Annual Review of Medicine. 1994;42:491–503
  33. Vallance P, Collier J. Biology and clinical relevance of nitric oxide. British Medical Journal. 1994;309:45
  34. Van de Ree MA, Huisman MV, de Man FH, et al. Impaired endothelium-dependent vasodilation in type 2 diabetes mellitus and the lack of effect of simvastatin. Cardiovascular Research. 2001;52:299–305

PII: S1056-8727(05)00041-3

doi: 10.1016/j.jdiacomp.2005.04.002

Journal of Diabetes and Its Complications
Volume 19, Issue 6 , Pages 347-355 , November 2005

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