Journal of Diabetes and Its Complications
Volume 19, Issue 6 , Pages 335-338 , November 2005

Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy

  • Piotr Skopiński

      Affiliations

    • Department of Ophthalmology, 2nd Faculty of Medicine, Warsaw Medical University, Poland
    • Department of Histology and Embryology, Center of Biostructure Research, Warsaw Medical University, Poland
    • Corresponding Author InformationCorresponding authors. Department of Ophthalmology, 2nd Faculty of Medicine, Warsaw Medical University, Poland. Tel. +48 22 643 41 46; fax: +48 22 643 41 46.
    • ,
  • Ewa Rogala

      Affiliations

    • 3rd Department Lung Diseases, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    • ,
  • Barbara Duda-Król

      Affiliations

    • 3rd Department of Internal Medicine, 2nd Faculty of Medicine, Warsaw Medical University, Poland
    • ,
  • Anna Lipińska

      Affiliations

    • Department of Internal Medicine, Faculty of Dentistry, Warsaw Medical University, Poland
    • ,
  • Ewa Sommer
    • ,
  • Joanna Chorostowska-Wynimko

      Affiliations

    • Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    • ,
  • Jerzy Szaflik

      Affiliations

    • Department of Ophthalmology, 2nd Faculty of Medicine, Warsaw Medical University, Poland
    • ,
  • Iwona Partyka

      Affiliations

    • Department of Ophthalmology, 2nd Faculty of Medicine, Warsaw Medical University, Poland
    • ,
  • Ewa Skopińska-Różewska

      Affiliations

    • Department of Pathology, Warsaw Medical University, Poland
    • Corresponding Author InformationCorresponding author. Tel/fax: +48 22 643 41 46.

Received 23 June 2004 ,Revised 7 February 2005 ,Accepted 15 February 2005.

References 

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  3. Beranek M, Kankova K, Benes P, Izakovicova-Holla L, Znojil V, Vlkova E, et al. Polymorphism R25P in the gene encoding transforming growth factor-beta is a newly identified risk factor for proliferative diabetic retinopathy. American Journal of Medical Genetics. 2002;109:278–283
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  6. Coughlin C, Salhany K, Wysocka M, Aruga E, Kurzawa H, Chang A, et al. Interleukin-12 and interleukin 18 synergistically induce murine tumor regression involves inhibition of angiogenesis. Journal of Clinical Investigation. 1998;101:1441–1452
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  11. Knott RM, Pascal MM, Ferguson C, Leiper J, Olson J, Muckersie E, et al. Regulation of transforming growth factor-beta, basic fibroblast growth factor, and vascular endothelial cell growth factor mRNA in peripheral blood leukocytes in patients with diabetic retinopathy. Metabolism. 1999;48:1172–1178
  12. Lee SC, Kim SH, Koh HJ, Kwon OW. TGF-betas synthesized by RPE cells have autocrine activity on mesenchymal transformation and cell proliferation. Yonsei Medical Journal. 2001;42:271–277
  13. Mahmoud RA, el-Ezz SA, Hegazy AS. Increased serum levels of interleukin-18 in patients with diabetic nephropathy. Italian Journal of Biochemistry. 2004;53:73–81
  14. Merendino RA, Gangemi S, Ruello A, Bene A, Losi E, Lonbardo G, et al. Serum levels of interleukin-18 and sICAM-1 in patients affected by breast cancer: Preliminary considerations. International Journal of Biological Markers. 2001;16:126–129
  15. Moriwaki Y, Yamamoto T, Shibutani Y, Aoki E, Tsutsumi Z, Takahashi S, et al. Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: Relationship with diabetic nephropathy. Metabolism. 2003;52:605–608
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  18. Sidky YA, Auerbach R. Lymphocyte induced angiogenesis: A quantitative and sensitive assay of graft-versus host reaction. Journal of Experimental Medicine. 1975;141:1084–1100
  19. Skopiński P, Szaflik J, Duda-Król B, Nartowska J, Sommer E, Chorostowska-Wynimko J, et al. Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone. International Journal of Molecular Medicine. 2004;14:

PII: S1056-8727(05)00024-3

doi: 10.1016/j.jdiacomp.2005.02.008

Journal of Diabetes and Its Complications
Volume 19, Issue 6 , Pages 335-338 , November 2005

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