Journal of Diabetes and Its Complications
Volume 18, Issue 3 , Pages 165-168 , May 2004

Homocysteine concentrations in type 2 diabetic patients with silent myocardial ischemia: A predictive marker

  • İlhan Tarkun

      Affiliations

    • Corresponding Author InformationCorresponding author. Yahya kaptan Mh. Gündönümü Sk., A-19 Blok Daire 17, Bekirpaşa, İzmit, Turkey. Tel.: +90-262-3114502; fax: +90-262-2335488
    • Department of Endocrinology and Metabolism, Kocaeli University, İzmit, Turkey
    • ,
  • Berrin Çetinarslan

      Affiliations

    • Department of Endocrinology and Metabolism, Kocaeli University, İzmit, Turkey
    • ,
  • Zeynep Cantrk

      Affiliations

    • Department of Endocrinology and Metabolism, Kocaeli University, İzmit, Turkey
    • ,
  • Pinar Tarkun

      Affiliations

    • Department of Internal Medicine, Kocaeli University, İzmit, Turkey
    • ,
  • Ayşen Aaçdiken

      Affiliations

    • Department of Cardiology, Kocaeli University, İzmit, Turkey
    • ,
  • Baki Komsuolu

      Affiliations

    • Department of Cardiology, Kocaeli University, İzmit, Turkey

Received 25 July 2003 ,Revised 20 November 2003 ,Accepted 12 December 2003.

References 

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  2. Barry S, Horowitz H, Ginsberg N. Dyslipidemia. In:  DeFronzo RA editors. Current management of diabetes mellitus. St. Louis, MO: Mosby-Year Book; 1998;p. 123–133
  3. Buysschaert M, Dramais A, Wallemavq P, Hermans M. Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy and insulin resistance. Diabetes Care. 2000;23:1816–1822
  4. Cohn PF. Prognosis for patients with different types of silent CAD. Circulation. 1987;5:33–35
  5. Gazzuruso C, Garzaniti A, Giordanetti S, Falcone C, Fratino P. Silent coronary artery disease in type 2 diabetes mellitus: the role of lipoprotein (a), homocysteine and apo (a) polymorphism. Cardiovascular Diabetology. 2002;1:1–9
  6. Hoogeveen EK, Kostense PJ, Beks PJ, Mackaay AJ, Jacobs C, Bouter LM, et al. Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin dependent diabetes mellitus: a population based study. Arteriosclerosis, Thrombosis, and Vascular Biology. 1998;18:133–138
  7. Hoogeveen EK, Kostense PJ, Jacobs C, Dekker JM, Nijpels G, Hein RJ, et al. Hyper homocysteinemia increases risk of death, especially in type 2 diabetes: 5 year follow-up of the Hoorn Study. Circulation. 2000;101:1506–1511
  8. Koistinen MJ. Prevalence of symptomatic myocardial ischemia in diabetic patients. British Medical Journal. 1990;301:92–95
  9. Meigs J, Jacques P, Selhub J, Singer D, Nathan D, Rifal N, et al. Fasting plasma homocysteine levels in the insulin resistance syndrome. The Framingham Offspring Study. Diabetes Care. 2001;24:1403–1411
  10. Milan Study on Atherosclerosis and Diabetes (MISAD) Group . Prevalence of unrecognized silent myocardial ischemia and its association with atherosclerotic risk factors in non-insulin dependent diabetes mellitus. American Journal of Cardiology. 1997;79:134–139
  11. Okada E, Oida K, Tada H, Asazuma K, Eguchi K, Tohda G, et al. Hyperhomocysteinemia is a risk factor for coronary arteriosclerosis an Japanese patients with type 2 diabetes. Diabetes Care. 1999;22:484–490
  12. Tabibiazar R, Edelman S. Silent ischemia in people with diabetes: a condition that must be heard. Clinical Diabetes. 2003;21:5–8
  13. Weiner DA, Ryan TJ, Pearsons L, Fisher LD, Chaitman BR, Sheffild LT, et al. Significance of silent myocardial ischemia during exercise testing in patients with diabetes mellitus: a report from Coronary Artery Surgery Study (CASS) Registry. American Journal of Cardiology. 1991;68:729–734
  14. Welch GN, Lascalzo J. Homocysteine and atherothrombosis. New England Journal of Medicine. 1998;338:1042–1050
  15. Yeromenko Y, Lavie L, Levy Y. Homocysteine and cardiovascular risk in patients with diabetes mellitus. Nutrition Metabolism and Cardiovascular Diseases. 2001;11:108–116

PII: S1056-8727(03)00115-6

doi: 10.1016/j.jdiacomp.2003.12.002

Journal of Diabetes and Its Complications
Volume 18, Issue 3 , Pages 165-168 , May 2004

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