Journal of Diabetes and Its Complications
Volume 18, Issue 1 , Pages 42-46 , 2 January 2004

Cognitive function in Japanese elderly with type 2 diabetes mellitus

  • Nanaka Mogi

      Affiliations

    • Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan
  • ,
  • Hiroyuki Umegaki

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +81-52-744-2365; fax: +81-52-744-2371
    • Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan
  • ,
  • Ayako Hattori

      Affiliations

    • Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan
  • ,
  • Noriki Maeda

      Affiliations

    • Department of Endocrinology, Gifu Prefectural Tajimi Hospital, 5-161 Maehata-Cho, Tajimi, Gifu, 507-8522, Japan
  • ,
  • Hisayuki Miura

      Affiliations

    • Department of Internal Medicine, Chubu National Hospital, 36-3, Gengo, Morioka, Obu, Aichi, 474-8511, Japan
  • ,
  • Masafumi Kuzuya

      Affiliations

    • Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan
  • ,
  • Hiroshi Shimokata

      Affiliations

    • Department of Epidemiology, National Institute for Longevity Sciences 36-3, Gengo, Morioka, Obu, Aichi, 474-8511, Japan
  • ,
  • Fujiko Ando

      Affiliations

    • Department of Epidemiology, National Institute for Longevity Sciences 36-3, Gengo, Morioka, Obu, Aichi, 474-8511, Japan
  • ,
  • Hideki Ito

      Affiliations

    • Department of Endocrinology, Tokyo Tama Metropolitan Geriatric Medical Center, 1-7-1, Aoba-Cho, Higashimurayama, Tokyo, 189-0002, Japan
  • ,
  • Akihisa Iguchi

      Affiliations

    • Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan

Received 19 January 2003 ,Revised 25 June 2003 ,Accepted 17 July 2003.

References 

  1. American Psychiatric Association . Diagnostic and statistical manual of mental disorders (DSM-III-R). 3rd rev. ed.. Washington, DC: Author; 1987;
  2. American Psychiatric Association . Diagnostic and statistical manual of mental disorders (DSM-IV). 4 ed.. Washington, DC: Author; 1994;
  3. Atiea JA, Moses JL, Sinclair AJ. Neuropsychological function in order subjects with non-insulin-dependent diabetes mellitus. Diabetic Medicine. 1995;12:679–685
  4. Biessels GJ, der Heide LP, Kamal A, Bleys RLA, Gispen WH. Ageing and diabetes: implication for brain function. European Journal of Pharmacology. 2002;441:1–14
  5. Convit A, Wolf OT, Tarshish C, de Leon MJ. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among elderly. Proceedings of the National Academy of Sciences. 2003;100(4):2019–2022
  6. Folstein MF, Folstein SE, McHigh PR. “Mini-mental state”: a practical method of grading the cognitive function of patients for the clinician. Journal of Psychiatric Research. 1978;12:189–198
  7. Gradman TJ, Laws A, Thompson LW, Reaven GM. Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. Journal of the American Geriatrics Society. 1993;41:1305–1312
  8. Jagusch W, Cramon DY, Renner R, Hepp KD. Cognitive function and metabolic state in elderly diabetic patients. Diabetes, Nutrition & Metabolism. 1992;5:265–274
  9. Japan Atherosclerosis Society . Japan atherosclerosis society guidelines for diagnosis and treatment of atherosclerotic cardiovascular disease. 2002; Tokyo
  10. Mattlar CE, Falck B, Ronnemaa T, Hyyppa MT. Neuropsychological cognitive performance of patients with type-2 diabetes. Scandinavian Journal of Rehabilitation Medicine. 1985;17:101–105
  11. Meneilly GS, Cheung E, Tessier D, Yakura C, Tuokko H. The effect of improved glycemic control on cognitive functions in elderly patients with diabetes. Journal of Gerontology. 1993;48:M117–M121
  12. Miles WR, Root HF. Psychologic tests applied to diabetic patients. Archives of Internal Medicine. 1922;30:767–777
  13. Mohs RC, Rosen WG, Davis KL. The Alzheimer's Disease Assessment Scale: an instrument for assessing treatment efficacy. Psychopharmacology Bulletin. 1983;19:448–450
  14. Ott A, Stolk RP, Harskamp FV, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia—the Rotterdam study. Neurology. 1999;53:1937–1942
  15. Ott A, Stolk RP, Hofman A, Harskamp FV, Grobbee DE, Breteler MM. Association of diabetes mellitus and dementia: the Rotterdam study. Diabetologia. 1996;39:1392–1397
  16. Perlmuter LC, Hakami MK, Hodgson-Harrington C, Ginsberg J, Katz J, Singer DE, et al. Decreased cognitive function in aging non-insulin-dependent diabetic patients. American Journal of Medicine. 1984;77:1043–1048
  17. Reaven GM, Thompson LW, Nahum D, Haskins E. Relationship between hyperglycemia and cognitive function in older NIDDM patients. Diabetes Care. 1990;13:16–21
  18. Schorr RI, Ray WA, Daugherty JR, Griffin MR. Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas. Archives of Internal Medicine. 1997;157:1681–1686
  19. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D. Insulin in the brain: a hormonal regulator of energy balance. Endocrine Reviews. 1992;13(3):387–414
  20. Shinagawa F, Kobayashi S, Fujita K, Maekawa H. In: Japanese manual for the Wechsler Adult Intelligence Scale—Revised. Tokyo: Nihon-bunka-kagaku-sya; 1990;p. 115–118
  21. SPSS Inc.. SPSS Base 11.0J User's Guide. 2001; Tokyo
  22. Strachan MW, Deary IJ, Ewing FM, Frier BM. Is type 2 diabetes associated with an increased risk of cognitive dysfunction?. Diabetes Care. 1997;20:438–445
  23. Stroop JR. Studies of interference in serial verbal reactions. Journal of Experimental Psychology. 1935;18:643–662
  24. Ushida C, Umegaki H, Hattori A, Mogi N, Aoki S, Iguchi A. Assessment of brain atrophy in elderly subjects with diabetes mellitus by computed tomography. Geriatrics and Gerontology International. 2001;1:33–37
  25. Vanhanen M, Kovisto K, Kuusisto J, Mykkanen L, Helkala EL, Hanninen T, et al. Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care. 1988;21(3):398–402

PII: S1056-8727(03)00078-3

doi: 10.1016/S1056-8727(03)00078-3

Journal of Diabetes and Its Complications
Volume 18, Issue 1 , Pages 42-46 , 2 January 2004