Journal of Diabetes and Its Complications
Volume 18, Issue 3 , Pages 177-182 , May 2004

Oxidative stress-induced up-regulation of the chloride channel and Na+/Ca2+ exchanger during cataractogenesis in diabetic rats

  • Kota V Ramana

      Affiliations

    • Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 6-644 Basic Science Building, Galveston, TX 77555-0647, USA
    • ,
  • Deepak Chandra

      Affiliations

    • Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 6-644 Basic Science Building, Galveston, TX 77555-0647, USA
    • ,
  • Nancy K Wills

      Affiliations

    • Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555-0647, USA
    • ,
  • Aruni Bhatnagar

      Affiliations

    • Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40402, USA
    • ,
  • Satish K Srivastava

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-409-772-3926; fax: +1-409-772-9679
    • Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 6-644 Basic Science Building, Galveston, TX 77555-0647, USA

Received 5 December 2002 ,Accepted 3 January 2003.

References 

  1. Ansari NH, Bhatnagar A, Fulep E, Khanna P, Srivastava SK. Trolox protects hyperglycemia-induced cataractogenesis in cultured rat lens. Research Communications in Chemical Pathology and Pharmacology. 1994;84:93–104
  2. Ansari NH, Srivastava SK. Allopurinol promotes and butylated hydroxy toluene prevents sugar-induced cataractogenesis. Biochemical and Biophysical Research Communications. 1990;168:939–943
  3. Bhatnagar A, Ansari NH, Wang L, Khanna P, Wang C, Srivastava SK. Calcium-mediated disintegrative globulization of isolated ocular lens fibers mimics cataractogenesis. Experimental Eye Research. 1995;61:303–310
  4. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding. Analytical Biochemistry. 1976;72:248–254
  5. Harding CV, Susan SR, Lo WK, Bobrow WFS, Maisel H, Chylack LT. The structure of human cataractous lens. In:  Maisel H editors. The ocular lens: structure, function and pathology. New York: Marcel Dekker; 1985;p. 367–404
  6. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–685
  7. Lehrach H, Diamond D, Wozney JM, Boedtker H. Ribonucleic acid molecular weight determination by gel electrophoresis under denaturating conditions: A critical reexamination. Biochemistry. 1977;16:4743–4751
  8. Mangini NJ, Haugh-Scheidt L, Valle JE, Cargoe EJ, Ripps H, Kennedy BG. Sodium–calcium exchanger in cultured human retinal pigment epithelium. Experimental Eye Research. 1997;65:821–834
  9. Mathias RT, Rae JL, Baldo GJ. Physiological properties of the normal lens. Physiological Reviews. 1997;77:21–50
  10. Rafferty NS. Lens morphology. In:  Maisel H editors. The ocular lens: structure, function and pathology. New York: Marcel Dekker; 1985;p. 1–60
  11. Srivastava SK, Wang LF, Ansari NH, Bhatnagar A. Calcium homeostasis of isolated single cortical fibers of rat lens. Investigative Ophthalmology and Visual Science. 1997;38:2300–2312
  12. Stobrawa SM, Breiderhoff T, Takamori S, Engel D, Schweizer M, Zdebik AA, et al. Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron. 2001;29:185–196
  13. Trevithick JR, Robertson J, Mitton KP. Vitamin E and the eye. In:  Packer L,  Fuchs J editor. Vitamin E in health and disease. New York: Marcel Dekker; 1993;p. 873–928
  14. Tunstall MJ, Eckert R, Donaldson P, Kistler J. Localised fiber cell swelling characteristic of diabetic cataract can be induced in normal rat lens using the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid. Ophthalmic Research. 1999;31:317–320
  15. Varma SD, Devamanoharan PS, Ali AH. Prevention of intracellular oxidative stress to lens by pyruvate and its ester. Free Radic Res. 1998;28:131–135
  16. Wang L, Bhatnagar A, Ansari NH, Dhir P, Srivastava SK. Mechanism of calcium-induced disintegrative globulization of rat lens fiber cells. Investigative Ophthalmology and Visual Science. 1996;37:915–922
  17. Wang LF, Christensen BN, Bhatnagar A, Srivastava SK. Role of calcium-dependent protease(s) in globulization of isolated rat lens cortical fiber cells. Investigative Ophthalmology and Visual Science. 2001;42:194–199
  18. Wang LF, Dhir P, Bhatnagar A, Srivastava SK. Contribution of osmotic changes to disintegrative globulization of single cortical fibers isolated from rat lens. Experimental Eye Research. 1997;65:267–275
  19. Wang LW, Chen LX, Jacob TJC. The role of ClC-3 volume-activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition. Journal of Physiology (London). 2000;524:63–75
  20. Wills NK, Weng T-X, Mo L, Hellmich HA, Yu TW, Godley BF. Chloride channel expression in cultured human RPE cells: response to oxidative stress. Investigative Ophthalmology and Visual Science. 2000;41:4247–4255
  21. Young MA, Tunstall MJ, Kistler J, Donaldson PJ. Blocking chloride channels in the rat lens: localized changes in tissue hydration support the existence of a circulating chloride flux. Investigative Ophthalmology and Visual Science. 2000;41:3049–3055
  22. Zhang JJ, Jacob TJ. Volume regulation in the bovine lens and cataract. The involvement of chloride channels. Journal of Clinical Investigation. 1996;97:971–978

PII: S1056-8727(03)00003-5

doi: 10.1016/S1056-8727(03)00003-5

Journal of Diabetes and Its Complications
Volume 18, Issue 3 , Pages 177-182 , May 2004

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