Journal of Diabetes and Its Complications
Volume 17, Issue 4 , Pages 169-178 , July 2003

Prognostic value of QT interval parameters in type 2 diabetes mellitus: Results of a long-term follow-up prospective study

Received 18 April 2002 ,Revised 21 July 2002 ,Accepted 25 July 2002.

References 

  1. Arildsen H, May O, Christiansen EH, Damsgaard EM. Increased QT dispersion in patients with insulin-dependent diabetes mellitus. International Journal of Cardiology. 1999;71:235–242
  2. Bazzet HD. An analysis of the time relations of electrocardiograms. Heart. 1920;7:353–370
  3. Bland JM, Altman DG. Statistical methods for assessing agreements between two methods of clinical measurement. Lancet. 1986;1(8476):307–310
  4. Boesrsma E, Pieper KS, Steyerberg EW, Wilcox RG, Chang WC, Lee KL, et al. Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation: results from an international trial of 9461 patients. for the PURSUIT Investigators Circulation. 2000;101:2257–2267
  5. Brendorp B, Elming H, Jun L, Kober L, Malik M, Jensen GB, et al. QT dispersion has no prognostic information for patients with advanced congestive heart failure and reduced left ventricular systolic function. for the Diamond Study Group Circulation. 2001;103:831–835
  6. Brooksby P, Batin PD, Nolan J, Lindsay SJ, Andrews R, Mullen M, et al. The relationship between QT intervals and mortality in ambulant patients with chronic heart failure .The United Kingdom Heart Failure Evaluation and Assessment of Risk Trial (UK-HEART). European Heart Journal. 1999;20:1335–1341
  7. Cardoso C, Salles G, Bloch K, Deccache W, Siqueira-Filho AG. Clinical determinants of increased QT dispersion in patients with diabetes mellitus. International Journal of Cardiology. 2001;79:253–262
  8. Christensen PK, Gall MA, Major-Pedersen A, Sato A, Rossing P, Breum L, et al. QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes. Scandinavian Journal of Clinical and Laboratory Investigation. 2000;60:323–332
  9. Concato J, Feinstein AR, Holford TR. The risk of determining risk in multivariate models. Annals of Internal Medicine. 1993;118:201–210
  10. Curb JD, Rodriguez BL, Burchfiel CM, Abbott RD, Chiu D, Yano K. Sudden death, impaired glucose tolerance and diabetes in Japanese American men. Circulation. 1995;91:2591–2595
  11. Dabrowski A, Kramarz E, Piotrowicz R, Kubik L. Predictive power of increased QT dispersion in ventricular extrasystoles and in sinus beats for risk stratification after myocardial infarction. Circulation. 2000;101:1693–1697
  12. Day CP, McComb JM, Campbell RWF. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. British Heart Journal. 1990;63:342–344
  13. Day CP, McComb JM, Matthews J, Campbell RWF. Reduction in QT dispersion by sotalol following myocardial infarction. European Heart Journal. 1991;12:423–427
  14. de Bruyne MC, Hoes AW, Kors JA, Hofman A, van Bemmel JH, Grobbee DE. QTc dispersion predicts cardiac mortality in the elderly. The Rotterdam Study. Circulation. 1998;97:467–472
  15. Dekker JM, Feskens EJ, Schouten EG, Klootwijk P, Pool J, Kromhout D. QTc duration is associated with levels of insulin and glucose tolerance. The Zutphen Elderly Study. Diabetes. 1996;45:376–380
  16. Dinneen SF, Gerstein HC. The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview of the literature. Archives of Internal Medicine. 1997;157:1413–1418
  17. Earle KA, Mishra B, Morocutti A, Barnes D, Chambers J, Viberti GC. QT dispersion in microalbuminuric type 1 diabetic patients without myocardial ischemia. Journal of Diabetes and its Complications. 2000;14:277–280
  18. Festa A, D'Agostino R, Rautaharju P, Mykkänen L, Haffner SM. Relation of systemic blood pressure, left ventricular mass, insulin sensitivity, and coronary artery disease to QT interval duration in nondiabetic and type 2 diabetic subjects. American Journal of Cardiology. 2000;86:1117–1122
  19. Florkowski CM, Scott RS, Coope PA, Moir CL. Predictors of mortality from type 2 diabetes mellitus in Canterbury, New Zealand; a ten-year cohort study. Diabetes Research and Clinical Practice. 2001;53:113–120
  20. Ford ES, DeStefano F. Risk factors for mortality from all-causes and from coronary heart disease among persons with diabetes. American Journal of Epidemiology. 1991;133:1220–1230
  21. Gall MA, Borch-Johnsen K, Hougaard P, Nielsen FS, Parving HH. Albuminuria and poor glycemic control predict mortality in NIDDM. Diabetes. 1995;44:1303–1309
  22. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. New England Journal of Medicine. 1998;339:229–234
  23. Hu FB, Stampfer MJ, Solomon CG, Liu S, Willett WC, Speizer FE, et al. The impact of diabetes mellitus on mortality from all-causes and coronary heart disease in women. Archives of Internal Medicine. 2001;161:1717–1723
  24. Ko GT, Chan JC, Critchley JA, Cockram CS. Cardiovascular disease in Chinese type 2 diabetic women is associated with a prolonged QTc interval. International Journal of Cardiology. 2000;76:75–80
  25. Kors JA, van Herpen G, van Bemmel JH. QT dispersion as an attribute of T-loop morphology. Circulation. 1999;99:1458–1463
  26. Laakso M, Lehto S, Penttilä I, Pyörälä K. Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes. Circulation. 1993;88:1421–1430
  27. Larsen JA, Kadish AH. Effects of gender on cardiac arrhythmias. Journal of Cardiovascular Electrophysiology. 1998;9:655–664
  28. Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. Journal of the American College of Cardiology. 2000;36:1749–1766
  29. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure, the Framingham study. New England Journal of Medicine. 1971;285:1441–1449
  30. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death: structure, function and time dependence of risk. Circulation. 1992;85(Suppl. I):I2–I10
  31. Naas AAO, Davidson NC, Thompson C, Cummings F, Ogston AS, Jung RT, et al. QT and QTc dispersion are accurate predictors of cardiac death in newly diagnosed non-insulin-dependent diabetes: cohort study. British Medical Journal. 1998;316:745–746
  32. Niskanen L, Turpeinen A, Penttilä I, Uusitupa MIJ. Hyperglycemia and compositional lipoprotein abnormalities as predictors of cardiovascular mortality in type 2 diabetes. Diabetes Care. 1998;21:1861–1869
  33. Oikarinen L, Nieminen MS, Viitasalo M, Toivonen L, Wachtell K, Papademetriou V, et al. Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients. The LIFE study. The Losartan Intervention for Endpoint Reduction. Journal of Hypertension. 2001;19:1883–1891
  34. Olivarius NF, Andreasen AH. Five-year all-cause mortality of 1323 newly diagnosed middle-aged and elderly diabetic patients. Journal of Diabetes and its Complications. 1997;11:83–89
  35. Prineas RJ, Crow RS, Blackburn H. The Minnesota code manual of electrocardiographic findings, standards and procedures for measurement and classification. Littleton, MA: J. Wright; 1982;
  36. Sawicki PT, Kiwitt S, Bender R, Berger M. The value of QT interval dispersion for identification of total mortality risk in non-insulin-dependent diabetes mellitus. Journal of Internal Medicine. 1998;243:49–56
  37. Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. for the Multiple Risk Factor Intervention Trial Research Group Diabetes Care. 1993;16:434–444
  38. Turrini P, Corrado D, Basso C, Nava A, Bauce B, Thiene G. Dispersion of ventricular depolarization–repolarization: a noninvasive marker for risk stratification in arrhythmogenic right ventricular cardiomyopathy. Circulation. 2001;103:3075–3080
  39. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–853
  40. Veglio M, Borra M, Stevens LK, Fuller JH, Perin PC. The relation between QTc interval prolongation and diabetic complications. The EURODIAB IDDM Complication Study Group. Diabetologia. 1999;42:68–75
  41. Vilbergsson S, Sigurdsson G, Sigvaldason H, Sigfusson N. Coronary heart disease mortality amongst non-insulin-dependent diabetic subjects in Iceland: the independent effect of diabetes. The Reykjavic Study 17-year follow up. Journal of Internal Medicine. 1998;244:309–316
  42. Wei K, Dorian P, Newman D, Langer N. Association between QT dispersion and autonomic dysfunction in patients with diabetes mellitus. Journal of the American College of Cardiology. 1995;26:859–863
  43. Wei M, Gaskill SP, Haffner SM, Stern MP. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. Diabetes Care. 1998;21:1167–1172
  44. Weiderpass E, Gridley G, Nyrén O, Pennello G, Landström AS, Ekbom A. Cause-specific mortality in a cohort of patients with diabetes mellitus: a population-based study in Sweden. Journal of Clinical Epidemiology. 2001;54:802–809
  45. Whitsel EA, Boyko EJ, Siscovick DS. Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes. Diabetes Care. 2000;23:241–247
  46. World Health Organization (1985). Diabetes mellitus. Tech. Rep. Ser. 727, World Health Organization, Geneve.
  47. Zabel M, Klingenheben T, Franz MR, Hohnloser SH. Assessment of QT dispersion for prediction of mortality or arrhythmic events after myocardial infarction. Results of a prospective, long-term, follow-up study. Circulation. 1998;97:2543–2550

PII: S1056-8727(02)00206-4

doi: 10.1016/S1056-8727(02)00206-4

Journal of Diabetes and Its Complications
Volume 17, Issue 4 , Pages 169-178 , July 2003

Article Tools

* Image Usage & Resolution