Journal of Diabetes and Its Complications
Volume 17, Issue 2 , Pages 66-72 , March 2003

Correlations between surrogate measures of insulin resistance and cardiovascular risk factors in obese and overweight patients

  • Israel Lerman

      Affiliations

    • Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14000 México City, Mexico
    • Corresponding Author InformationCorresponding author. Tel.: +52-55-5731200x2405; fax: +52-55-2722484
    • ,
  • Antonio R. Villa

      Affiliations

    • Clinical Epidemiology Unit, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México City, Mexico
    • ,
  • Juan Manuel Rı́os Torres

      Affiliations

    • Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14000 México City, Mexico
    • ,
  • Laura Elena Tamez

      Affiliations

    • Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14000 México City, Mexico
    • ,
  • Francisco Gómez Pérez

      Affiliations

    • Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14000 México City, Mexico
    • ,
  • Sonia Luna del Villar Velasco

      Affiliations

    • Central Laboratory, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, México City, Mexico
    • ,
  • Juan Antonio Rull Rodrigo

      Affiliations

    • Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14000 México City, Mexico

Received 7 December 2001 ,Revised 2 July 2002 ,Accepted 8 July 2002.

References 

  1. American Diabetes Association. Consensus development conference on insulin resistance. Diabetes Care. 1998;21:310–314
  2. Belfiore F, Jannello S, Volpicelli G. Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels. Molecular Genetics and Metabolism. 1988;63:134–141
  3. Bergman N. The “metabolically obese” normal weight individual. American Journal of Clinical Nutrition. 1989;38:1512–1527
  4. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Targher G, et al. Prevalence of insulin resistance in metabolic disorders. The Bruneck Study. Diabetes. 1998;47:1643–1649
  5. Caro J. Insulin resistance in obese and nonobese man. Journal of Clinical Endocrinology and Metabolism. 1991;73:691–696
  6. Cederholm J, Wibell L. Insulin release and peripheral sensitivity at the oral glucose tolerance test. Diabetes Research and Clinical Practice. 1990;10:167–175
  7. DeFronzo R, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and ASCVD. Diabetes Care Reviews. 1991;14:173–194
  8. DeFronzo RA, Tobin JD, Andres R. The glucose clamp technique: a method for the quantification of beta cell sensitivity to glucose and of tissue sensitivity to insulin. American Journal of Physiology. 1979;237:E214–E223
  9. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. New England Journal of Medicine. 1996;334:952–957
  10. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  11. Ferranini E. Insulin resistance and hypersecretion in obesity. Journal of Clinical Investigation. 1997;100:1166–1173
  12. Ferrannini E, Bjorkman O, Reichard GA, Pilo A, Olsson M, Wahren J, et al. The disposal of an oral glucose load in healthy sujects. A cuantitative study. Diabetes. 1985;34:580–588
  13. Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G. On behalf of the European Group for the Study of Insulin Resistance (EGIR): insulin resistance and hypersecretion in obesity. Journal of Clinical Investigation. 1997;100:1166–1173
  14. Fulcher GR, Walker M, Alberti KGMM. The assesment of insulin action in vivo. In:  Alberti KGMM,  DeFronzo RA,  Keen H,  Zimmet P editor. International textbook of diabetes mellitus. New York: Wiley; 1992;p. 513–530
  15. Ginsberg H. Insulin resistance and cardiovascular disease. Journal of Clinical Investigation. 2000;106:453–458
  16. Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H. A prospective analysis of the HOMA model: the Mexico City Diabetes Study. Diabetes Care. 1996;19:1138–1141
  17. Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio Heart Study. Diabetes Care. 1997;20:1087–1092
  18. Hollenbeck CB, Chen N, Chen Y-DI, Reaven GM. Relationship between the plasma insulin response to oral glucose and insulin-stimulated glucose utilization in normal subjects. Diabetes. 1984;33:460–463
  19. Kahn BB, Flier JS. Obesity and insulin resistance. Journal of Clinical Investigation. 2000;106:473–481
  20. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple accurate method for assessing insulin sensitivity in humans. Journal of Clinical Endocrinology and Metabolism. 2000;85:2402–2410
  21. Laakso M. How good a marker is insulin level for insulin resistance?. American Journal of Epidemiology. 1993;137:959–965
  22. Lindahl B, Asplund K, Hallmans G. High serum insulin, insulin resistance and their associations with cardiovascular risk factors The Northern Sweden MONICA population study. Journal of Internal Medicine. 1993;234:263–270
  23. Matsuda M, DeFronzo R. Insulin sensitivity indices obtained from oral glucose tolerance testing. Diabetes Care. 1999;22:1462–1470
  24. McAuley KA, Williams SM, Mann JI, Walker RJ, Lewis-Barned NJ, Temple LA, et al. Diagnosing insulin resistance in the general population. Diabetes Care. 2001;24:460–464
  25. Methews DR, Hosker JP, Rudensky AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentration in man. Diabetologia. 1985;28:412–419
  26. Modan M, Halkin H, Almong S, Lusky A, Eshkol A, Shelfi M, et al. Hyperinsulinemia: a link between hypertension, obesity and glucose intolerance. Journal of Clinical Investigation. 1985;75:809–817
  27. O'Dea K, Rowley KG. Macrovascular disease risk factors and insulin resistance in Aboriginal and Torres Strait Islander people. Journal of Diabetes and its Complications. 2002;16:9–16
  28. Olefsky J, Farquhar JW, Reaven GM. Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects. Diabetes. 1973;22:507–513
  29. Radziuk J. Insulin sensitivity and its measurement: structural commonalities among the methods. Journal of Clinical Endocrinology and Metabolism. 2000;85:4426–4433
  30. Reaven G. Banting lecture: role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607
  31. Reaven GM. Obesity:basic aspects and clinical implications. Medical Clinics of North America. 1989;73:1–264
  32. Reaven GM, Brand RJ, Chen YD, Mathur AK, Goldfine I. Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals. Diabetes. 1993;42:1324–1332
  33. Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonals JM, Parrot M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clinical Chemistry. 2002;48:436–472
  34. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Järvinen H, Van Haeften T, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23:295–301
  35. Yeni-Komshian H, Carantoni M, Abbasi F, Reaven GM. Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers. Diabetes Care. 2000;23:171–175

PII: S1056-8727(02)00201-5

Journal of Diabetes and Its Complications
Volume 17, Issue 2 , Pages 66-72 , March 2003

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