Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 27-28 , January 2003

Ob/ob mice as a model of delayed gastric emptying

  • Akihiro Asakawa

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • ,
  • Akio Inui

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-78-382-5862; fax: +81-78-797-0854
    • ,
  • Naohiko Ueno

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • ,
  • Susumu Makino

      Affiliations

    • Animal Care Center, Shionogi & Co., Ltd., Shiga, Japan
    • ,
  • Masaharu Uemoto

      Affiliations

    • Kobe City College of Nursing, Kobe, Japan
    • ,
  • Masayuki A Fujino

      Affiliations

    • First Department of Internal Medicine, Yamanashi Medical University, Yamanashi, Japan
    • ,
  • Masato Kasuga

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

Received 18 April 2002 ,Revised 20 June 2002 ,Accepted 26 June 2002.

References 

  1. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001;120:337–345
  2. Asakawa A, Inui A, Ueno N, Makino S, Fujino MA, Kasuga M. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice. Gastroenterology. 1999;116:1287–1292
  3. Barrachina MD, Martinez V, Wei JY, Tache Y. Leptin-induced decrease in four intake is not associated with changes in gastric emptying in lean mice. American Journal of Physiology. 1997;272:R1007–R1011
  4. Inui A. Feeding and body-weight regulation by hypothalamic neuropeptides-mediation of the actions of leptin. Trends in Neurosciences. 1999;22:62–67
  5. Inui A. Transgenic approach to the study of body weight regulation. Pharmacological Reviews. 2000;52:35–61
  6. Itoh Z. Motilin and clinical application. Peptides. 1997;18:593–608
  7. Nilsson PH. Diabetic gastroparesis: a review. Journal of Diabetes and its Complications. 1996;10:113–122
  8. Okano H, Inui A, Ueno N, Morimoto S, Ohmoto A, Miyamoto M, et al. EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion. Peptides. 1996;17:895–900
  9. Tanaka T, Mizumoto A, Mochiki E, Suzuki H, Itoh Z, Omura S. Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs. Journal of Pharmacology and Experimental Therapeutics. 1998;287:712–719

PII: S1056-8727(02)00198-8

Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 27-28 , January 2003

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