Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 27-28, January 2003

Ob/ob mice as a model of delayed gastric emptying

  • Akihiro Asakawa

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • ,
  • Akio Inui

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-78-382-5862; fax: +81-78-797-0854
    • ,
  • Naohiko Ueno

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    • ,
  • Susumu Makino

      Affiliations

    • Animal Care Center, Shionogi & Co., Ltd., Shiga, Japan
    • ,
  • Masaharu Uemoto

      Affiliations

    • Kobe City College of Nursing, Kobe, Japan
    • ,
  • Masayuki A Fujino

      Affiliations

    • First Department of Internal Medicine, Yamanashi Medical University, Yamanashi, Japan
    • ,
  • Masato Kasuga

      Affiliations

    • Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

Received 18 April 2002; received in revised form 20 June 2002; accepted 26 June 2002.

Abstract 

Diabetic gastroparesis is a well-recognized delay of gastric emptying in diabetic patients. We assessed the gastric emptying rate in ob/ob mice, a genetic model of obesity and diabetes. The basal gastric emptying rate in 22- to 27-week-old ob/ob mice was significantly lower than that in 10- to 11-week-old ob/ob mice (P<.01). Our results indicate that the ob/ob mice are a useful model not only of glucose intolerance but also of delayed gastric emptying as a diabetic complication.

Keywords:  Diabetic gastroparesis, Ob/ob mice, Gastric emptying

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PII: S1056-8727(02)00198-8

Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 27-28, January 2003

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