Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 29-33 , January 2003

Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

  • Hyun-Bae Kim

      Affiliations

    • Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
    • Graduate School of Physical Education, Kyung Hee University, Seoul, South Korea
  • ,
  • Mi-Hyeon Jang

      Affiliations

    • Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
  • ,
  • Min-Chul Shin

      Affiliations

    • Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
  • ,
  • Baek-Vin Lim

      Affiliations

    • Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
  • ,
  • Young-Pyo Kim

      Affiliations

    • Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
  • ,
  • Kyung-Ji Kim

      Affiliations

    • Graduate School of Physical Education, Kyung Hee University, Seoul, South Korea
  • ,
  • Ee-Hwa Kim

      Affiliations

    • Department of Meridianology, College of Oriental Medicine, Semyung University, Jechon, South Korea
  • ,
  • Chang-Ju Kim

      Affiliations

    • Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-2-961-0407; fax: +82-2-964-2195

Received 22 February 2002 ,Revised 15 April 2002 ,Accepted 22 April 2002.

References 

  1. Altman J, Bayer SA. Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal period. Journal of Comparative Neurology. 1990;301:365–381
  2. Biessels GJ, Kamal A, Ramakers GM, Urban IJ, Spruijt BM, Erkelens DW, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes. 1996;45:1259–1266
  3. Biessels GJ, Kappelle AC, Bravenboer B, Erkelens DW, Gispen WH. Cerebral function in diabetes mellitus. Diabetologia. 1994;37:643–650
  4. Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993;361:31–39
  5. Cameron HA, McEwen BS, Gould E. Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. Journal of Neuroscience. 1995;15:4687–4692
  6. Cameron HA, Woolley CS, McEwen BS, Gould E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience. 1993;56:337–344
  7. Carro E, Nunez A, Busigunia S, Torres-Aleman I. Circulating insulin-like growth factor 1 mediates effects of exercise on the brain. Journal of Neuroscience. 2000;20:2926–2933
  8. Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordberg C, Peterson DA, et al. Neurogenesis in the adult human hippocampus. Nature Medicine. 1998;4:1313–1317
  9. Fuchs E, Gould E. In vivo neurogenesis in the adult's brain: regulation and functional implications. European Journal of Neuroscience. 2000;12:2211–2214
  10. Gage FH, Kempermann G, Palmer TD, Peterson DA, Ray J. Multipotent progenitor cells in the adult dentate gyrus. Journal of Neurobiology. 1998;36:249–266
  11. Gómez-Pinilla F, So V, Kesslak JP. Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise. Neuroscience. 1998;85:53–61
  12. Gould E, Beylin A, Tanapat P, Reeves A, Shors TS. Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience. 1999;2:260–265
  13. Gould E, Tanapat P. Stress and hippocampal neurogenesis. Biological Psychiatry. 1999;46:1472–1479
  14. Jackson-Guilford J, Leander JD, Nisenbaum LK. The effect of streptozotocin-induced diabetes on cell proliferation in the rat dentate gyrus. Neuroscience Letters. 2000;293:91–94
  15. Johansson BB, Ohlsson AL. Environmental, social interaction, and physical activity as determinants of functional outcome after cerebral activity in the rat. Experimental Neurology. 1996;139:322–327
  16. Kempermann G, Kuhn HG, Gage FH. More hippocampal neurons in adult mice living in an enriched environmental. Nature. 1997;386:493–495
  17. Kim EH, Kim YJ, Lee HJ, Huh Y, Chung JH, Seo JC, et al. Acupuncture increases cell proliferation in dentate gyrus after transient global ischemia in gerbils. Neuroscience Letters. 2001;297:21–24
  18. Liu J, Solway K, Messing RO, Sharp FR. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. Journal of Neuroscience. 1998;18:7768–7778
  19. Neeper SA, Gomez-Pinilla F, Choi J, Cotman C. Exercise and brain neurotrophins. Nature. 1995;373:109
  20. Trejo JL, Carro E, Torres-Aleman I. Circulating insulin-like growth factor 1 mediates exercise-induced increases in the number of new neurons in the adult hippocampus. Journal of Neuroscience. 2001;21:1628–1634
  21. van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proceedings of the National Academy of Sciences of the United States of America. 1999;96:13427–13431
  22. van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience. 1999;2:266–270

PII: S1056-8727(02)00186-1

Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 29-33 , January 2003