Journal of Diabetes and Its Complications
Volume 17, Issue 2 , Pages 105-107 , March 2003

Leptin treatment ameliorates anxiety in ob/ob obese mice

  • Akihiro Asakawa

      Affiliations

    • Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan
  • ,
  • Akio Inui

      Affiliations

    • Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-78-382-5862; fax: +81-78-797-0845
  • ,
  • Toshio Inui

      Affiliations

    • Inui Clinic, Moriguchi, Osaka 570-0011, Japan
  • ,
  • Goro Katsuura

      Affiliations

    • Shionogi Research Laboratories, Shionogi and Co., Ltd., Koka, Shiga 520-3423, Japan
  • ,
  • Masayuki A Fujino

      Affiliations

    • First Department of Internal Medicine, Yamanashi Medical University, Tamaho, Yamanashi 409-3898, Japan
  • ,
  • Masato Kasuga

      Affiliations

    • Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

Received 25 March 2002 ,Accepted 19 April 2002.

References 

  1. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB. The role of corticotropin-releasing factor in depression and anxiety disorders. Journal of Endocrinology. 1999;160:1–12
  2. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Fujimiya M, et al. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology. 2001;74:143–147
  3. Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino MA, Kasuga M. Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. Peptides. 1999;20:1445–1448
  4. Chrousos GP. The role of stress and the hypothalamic–pituitary–adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. International Journal of Obesity and Related Metabolic Disorders. 2000;24:S50–S55
  5. Greeno CG, Wing RR. Stress-induced eating. Psychological Bulletin. 1994;115:444–464
  6. Inui A. Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin. Trends in Neurosciences. 1999;22:62–67
  7. Inui A. Transgenic study of energy homeostasis equation: implications and confounding influences. FASEB Journal. 2000;14:2158–2170
  8. Inui A. Transgenic approach to the study of body weight regulation. Pharmacological Review. 2000;52:35–61
  9. Inui A. Eating behavior in anorexia nervosa—an excess of both orexigenic and anorexigenic signalling?. Molecular Psychiatry. 2001;6:620–624
  10. Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Natural Review of Neurosciences. 2001;2:551–560
  11. Kuhn CM, Cochrane C, Feinglos MN, Surwit RS. Exaggerated peripheral responses to catecholamines contributes to stress-induced hypoglycemia in the ob/ob mouse. Pharmacology, Biochemistry and Behavior. 1987;26:491–495
  12. Ogawa Y, Masuzaki H, Hosoda K, Aizawa-Abe M, Suga J, Suda M, et al. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes. 1999;48:1822–1829
  13. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540–543
  14. Picard F, Richard D, Huang Q, Deshaies Y. Effects of leptin adipose tissue lipoprotein lipase in the obese ob/ob mouse. International Journal of Obesity and Related Metabolic Disorders. 1998;22:1088–1095
  15. Schwartz MW, Seeley RJ. Seminars in medicine of the Beth Israel Deaconess Medical Center, Neuroendocrine responses to starvation and weight loss. New England Journal of Medicine. 1997;336:1802–1811
  16. Solomon J, Mayer J. The effect of adrenalectomy on the development of the obese—hyperglycemic syndrome in ob/ob mice. Endocrinology. 1973;93:510–513
  17. Vaswani K, Tejwani GA, Mousa S. Stress induced differential intake of various diets and water by rat: the role of the opiate system. Life Science. 1983;32:1983–1996
  18. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–432

PII: S1056-8727(02)00185-X

Journal of Diabetes and Its Complications
Volume 17, Issue 2 , Pages 105-107 , March 2003