Journal of Diabetes and Its Complications
Volume 17, Issue 2 , Pages 105-107, March 2003

Leptin treatment ameliorates anxiety in ob/ob obese mice

  • Akihiro Asakawa

      Affiliations

    • Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan
    • ,
  • Akio Inui

      Affiliations

    • Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-78-382-5862; fax: +81-78-797-0845
    • ,
  • Toshio Inui

      Affiliations

    • Inui Clinic, Moriguchi, Osaka 570-0011, Japan
    • ,
  • Goro Katsuura

      Affiliations

    • Shionogi Research Laboratories, Shionogi and Co., Ltd., Koka, Shiga 520-3423, Japan
    • ,
  • Masayuki A Fujino

      Affiliations

    • First Department of Internal Medicine, Yamanashi Medical University, Tamaho, Yamanashi 409-3898, Japan
    • ,
  • Masato Kasuga

      Affiliations

    • Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

Received 25 March 2002; accepted 19 April 2002.

Abstract 

We investigated whether or not administered leptin influences anxiety-like behavior in ob/ob mice. Repeated intraperitoneal administrations of leptin were continued for 5 days. Anxiety was assessed in the standard elevated plus maze. Body weight was measured daily. Repeated administrations of leptin significantly increased the percentage of the total number of entries in the open arms and the number of total entries. The body weight was significantly reduced by 13.2% after treatment. Leptin treatment ameliorated not only obesity but also anxiety in ob/ob mice. Our results indicate that the treatment of obesity may lead to the solution of psychological problems.

Keywords:  Leptin, ob/ob mice, Anxiety, Locomotor activity, Obesity

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PII: S1056-8727(02)00185-X

Journal of Diabetes and Its Complications
Volume 17, Issue 2 , Pages 105-107, March 2003

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