Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 16-21 , January 2003

Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes

  • Junnosuke Miura

      Affiliations

    • Diabetes Center, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-3353-8111x27011; fax: +81-3-3358-1941
  • ,
  • Sho-ichi Yamagishi

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 67, Asahi-machi, Kurume 830-0011, Japan
  • ,
  • Yasuko Uchigata

      Affiliations

    • Diabetes Center, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
  • ,
  • Masayoshi Takeuchi

      Affiliations

    • Department of Biochemistry, Faculty of Pharmaceutical Science, Hokuriku University, 3 Ho Kanagawa-machi, Kanazawa 920-1148, Japan
  • ,
  • Hiroshi Yamamoto

      Affiliations

    • Department of Biochemistry, Kanazawa University School of Medicine, 13-1, Takaramachi, Kanazawa 920-8640, Japan
  • ,
  • Zenji Makita

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, 67, Asahi-machi, Kurume 830-0011, Japan
  • ,
  • Yasuhiko Iwamoto

      Affiliations

    • Diabetes Center, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan

Received 1 November 2001 ,Revised 5 March 2002 ,Accepted 15 April 2002.

References 

  1. Ahmed MU, Thorpe SR, Baynes JW. Identification of N-carboxymethyllysine as a degradation product of fructoselysine in glycated protein. Journal of Biological Chemistry. 1986;261:4889–4894
  2. Besswenger PJ, Makita Z, Curphery TJ, Moore LL, Jean S, Johnsen TB, et al. Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes. Diabetes. 1995;44:824–829
  3. Brownlee M, Cerami A, Vlassara H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. New England Journal of Medicine. 1988;318:1315–1321
  4. Fu MX, Requena JR, Jenkins AJ, Lyons TJ, Baynes JW, Thorpe SR. The advanced glycation end product, N-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions. Journal of Biological Chemistry. 1996;271:9982–9986
  5. Hammes HP, Brownlee M, Lin J, Schleicher E, Bretzel RG. Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product N-(carboxymethyl) lysine independently of glycohaemoglobin concentrations. Diabetologia. 1999;42:603–607
  6. Hayase F, Nagaraj RH, Miyata S, Njoroge FG, Monnier VM. Aging of proteins: immunological detection of a glucose-derived pyrrole formed during Maillard reaction in vivo. Journal of Biological Chemistry. 1989;263:3758–3764
  7. Izuhara Y, Miyata T, Ueda Y, Suzuki D, Asahi K, Inagi R, et al. A sensitive and specific ELISA for plasma pentosidine. Nephrology, Dialysis, Transplantation. 1999;14:576–580
  8. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, et al. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. Journal of Biological Chemistry. 1999;274:31740–31749
  9. Makita Z, Bucala R, Rayfield EJ, Friedman EA, Kaufman AM, Korbet SM, et al. Reactive glycosylation endproducts in diabetic uraemia and treatment renal failure. Lancet. 1994;343:1519–1522
  10. Makita Z, Radoff S, Rayfield EJ, Yang Z, Skolnik E, Delanev V, et al. Advanced glycosylation end products in patients with diabetic nephropathy. New England Journal of Medicine. 1991;325:836–842
  11. Murata T, Nagai R, Ishibashi T, Inomata H, Ikeda K, Horiuchi S. The relationship between accumulation of advanced glycation endproducts and expression of vascular endothelial growth factor in human diabetic retinas. Diabetologia. 1997;40:764–769
  12. Nomura T, Odagiri R, Demura R, Akashi H, Demura H. Evaluation of a new radioimmunoassay kit for urinary albumin. Journal of Medicine and Pharmaceutical Science. 1989;22:213–220
  13. Raj DSC, Choudhury D, Welbourne TC, Levi M. Advanced glycation end products: a nephrologist's perspective. American Journal of Kidney Diseases. 2000;35:365–380
  14. Segawa Y, Shirao Y, Yamagishi S, Higashide T, Kobayashi M, Katsuno K, et al. Upregulation of retinal vascular endothelial growth factor mRNAs in spontaneously diabetic rats without ophthalmoscopic retinopathy. A possible participation of advanced glycation end products in the development of the early phase of diabetic retinopathy. Ophtalmic Research. 1998;30:333–339
  15. Sell DR, Lapolla A, Odetti P, Fogarty J, Monnier VM. Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM. Diabetes. 1992;41:1286–1292
  16. Sell DR, Monnier VM. Structure elucidation of a senescence cross-link from human extracellular matrix. Journal of Biological Chemistry. 1989;264:21597–21602
  17. Suzuki D, Miyata T, Saotome N, Horie K, Inagi R, Yasuda Y, et al. Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions. Journal of the American Society of Nephrology. 1999;10:822–832
  18. Takeuchi M, Makita Z, Yanagisawa K, Kameda Y, Koike T. Detection of noncarboxymethyllysine and carboxymethyllysine advanced glycation end products (AGE) in serum of diabetic patients. Molecular Medicine. 1999;5:393–405
  19. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus . Report of Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183–1197
  20. Vlassala H, Striker LJ, Teichberg S, Fuh H, Li YM, Steffes M. Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats. Proceedings of the National Academy of Sciences of the United States of America. 1994;91:11704–11708
  21. Wautier JL, Zoukourian C, Chappey O, Wautier MP, Guillausseau PJ, Cao R, et al. Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Journal of Clinical Investigation. 1996;97:238–243
  22. Yamagishi S, Fujimori H, Yonekura H, Yamamoto Y, Yamamoto H. Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells. Diabetologia. 1998;41:1435–1441
  23. Yamagishi S, Hsu CC, Taniguchi M, Harada S, Yamamoto Y, Ohsawa K, et al. Receptor-mediated toxicity to pericytes of advanced glycosylation end products. Biochemical and Biophysical Research Communications. 1995;213:681–687
  24. Yamagishi S, Yonekura H, Yamamoto Y, Katsuno K, Sato F, Mita I, et al. Advanced glycation end products-driven angiogenesis in vitro. Journal of Biological Chemistry. 1997;272:8723–8730

PII: S1056-8727(02)00183-6

Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 16-21 , January 2003