Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 7-10 , January 2003

Parameters of oxidative stress in children with Type 1 diabetes mellitus and their relatives

  • Jana Varvařovská

      Affiliations

    • Pediatric Clinic, Charles University Hospital, E. Beneše 13, 305 99, Plzeň, Czech Republic
    • Corresponding Author InformationCorresponding author. Tel.: +420-19-740-2212; fax: +420-19-742-3459
    • ,
  • Jaroslav Racek

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, Charles University Hospital, E. Beneše 13, 305 99, Plzeň, Czech Republic
    • ,
  • František Stožický

      Affiliations

    • Pediatric Clinic, Charles University Hospital, E. Beneše 13, 305 99, Plzeň, Czech Republic
    • ,
  • Jiřı́ Souček

      Affiliations

    • Pediatric Department, Hospital Karlovy Vary, Karlovy Vary, Czech Republic
    • ,
  • Ladislav Trefil

      Affiliations

    • Institute of Clinical Biochemistry and Laboratory Diagnostics, Charles University Hospital, E. Beneše 13, 305 99, Plzeň, Czech Republic
    • ,
  • Renata Pomahačová

      Affiliations

    • Pediatric Clinic, Charles University Hospital, E. Beneše 13, 305 99, Plzeň, Czech Republic

Received 26 July 2001 ,Revised 21 November 2001 ,Accepted 17 December 2001.

References 

  1. Asayama K, Uchida N, Hayashibe H, Dobashi K, Amemiya S, Kato K, et al. Antioxidants in the serum of children with insulin-dependent diabetes mellitus. Free Radical Biology & Medicine. 1993;15:597–602
  2. Cavan DA, Penny MA, Bain SC, Barnett AH. Molecular genetics of Type 1 diabetes mellitus. International textbook of diabetes mellitus. 2nd ed.. Chichester, NY: Wiley; 1997;
  3. Dominguez C, Ruiz E, Gussinye M, Carrascosa A. Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care. 1998;21:1736–1742
  4. Holeček V, Racek J. The significance of free radicals and glycosylation end-products (AGE) in diabetes mellitus. Klinicka Biochemie a Metabolismus. 1995;3:18–22
  5. Hunt JV, Dean RT, Wolff SP. Hydroxyl radical production in autooxidative glycosylation: glucose autooxidation as a cause of protein damage in the experimental glycation model of diabetes mellitus ageing. Biochemical Journal. 1988;256:205–212
  6. Leinonen JS, Alho H, Harmoinen A, Lehtimaki T, Knip M. Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM. Free Radical Research. 1998;29:159–164
  7. Mihara M, Uchiyama M, Fukasawa K. Thiobarbituric acid value in fresh homogenate of rat as parameter of lipid peroxidation in ageing, CCl4 intoxication and vitamin E deficiency. Biochemical Medicine. 1980;23:320–331
  8. Rabinovitch A. Free radicals as mediators of pancreatic islet beta-cell injury in autoimmune diabetes. Journal of Laboratory and Clinical Medicine. 1992;119:455–456
  9. Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochemical Pharmacology. 1998;15:1139–1149
  10. Racek J, Holeček V, Krejčová I. Clinical significance of extra- and intracellular antioxidative defence. In: Abstracts of the 12th IFCC European Congress of Clinical Chemistry, Basel (Switzerland), 17–21 August 1997. Rotkreuz, Switzerland: Medlab97 Labolite; 1997;p. 108–109
  11. Vlassaara H. Recent progression in the biologic and clinical significance of advanced glycosylation end-products. Journal of Laboratory and Clinical Medicine. 1994;124:19–30
  12. Willems D, Dorchy H, Dufrasne D. Serum antioxidant status and oxidized LDL in well-controlled young type 1 diabetic patients with and without subclinical complications. Atherosclerosis. 1998;137:S61–S64Supplement

PII: S1056-8727(01)00228-8

Journal of Diabetes and Its Complications
Volume 17, Issue 1 , Pages 7-10 , January 2003

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