Leukocyte–endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus

Kamiuchi, Kenji; Hasegawa, Goji; Obayashi, Hiroshi; Kitamura, Akane; Ishii, Michiyo; Yano, Miho; Kanatsuna, Takahiro; Yoshikawa, Toshikazu; Nakamura, Naoto

« Previous Next »Journal of Diabetes and Its Complications
Volume 16, Issue 5 , Pages 333-337, September 2002

Leukocyte–endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus

Kenji Kamiuchi
- The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 kajii-cho, Kawaramachi-Hirokoji, kamikyo-ku, Kyoto, 602-8566, Japan
Goji Hasegawa
- The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 kajii-cho, Kawaramachi-Hirokoji, kamikyo-ku, Kyoto, 602-8566, Japan
- Corresponding author. Tel.: +81-75-251-5505; fax: +81-75-252-3721
Hiroshi Obayashi
- Department of Clinical Research, Kyoto Microbiological Institute, Kyoto, Japan
Akane Kitamura
- The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 kajii-cho, Kawaramachi-Hirokoji, kamikyo-ku, Kyoto, 602-8566, Japan
Michiyo Ishii
- The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 kajii-cho, Kawaramachi-Hirokoji, kamikyo-ku, Kyoto, 602-8566, Japan
Miho Yano
- The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 kajii-cho, Kawaramachi-Hirokoji, kamikyo-ku, Kyoto, 602-8566, Japan
Takahiro Kanatsuna
- Department of Internal Medicine, Nishijin Hospital, Kyoto, Japan
Toshikazu Yoshikawa
- The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 kajii-cho, Kawaramachi-Hirokoji, kamikyo-ku, Kyoto, 602-8566, Japan
Naoto Nakamura
- The First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 kajii-cho, Kawaramachi-Hirokoji, kamikyo-ku, Kyoto, 602-8566, Japan

Received 22 August 2001; received in revised form 11 December 2001; accepted 17 December 2001.

Abstract

Background/aims: Glomerular infiltration with monocytes/macrophages has been implicated in the pathogenesis of diabetic nephropathy. In this study, we evaluated the relationship between the genetic polymorphism in leukocyte–endothelial adhesion molecule-1 (LECAM-1) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: We determined the frequency of the LECAM-1 P213S genotype in 102 diabetic patients with diabetic nephropathy, 90 diabetic patients with no evidence of diabetic nephropathy, and 200 healthy control individuals. Results: The frequency of the LECAM-1 213PP genotype and P allele in patients with diabetic nephropathy was significantly higher than that in patients without nephropathy (genotype 68% vs. 53%, χ²=6.78, P=.034; allele 83% vs. 72%, χ²=6.26, P=.012). The LECAM-1 P213 genotype was associated with a 1.86-fold increased risk for nephropathy independently of other risk factors. Conclusion: The data suggest that the LECAM-1 213PP genotype is a genetic risk factor for the development of nephropathy in type 2 diabetes mellitus.

Keywords: Adhesion molecule, LECAM-1, Diabetic nephropathy, Polymorphism