Journal of Diabetes and Its Complications
Volume 16, Issue 5 , Pages 352-358, September 2002

Elevated serum KL-6 concentrations in patients with diabetes mellitus

  • Toru Takahashi

      Affiliations

    • First Department of Medicine, School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, Japan
    • First Department of Biochemistry, School of Medicine, Sapporo Medical University, S-1, W-7, Chuo-ku, Sapporo 060-8556, Japan
    • Corresponding Author InformationCorresponding author. First Department of Biochemistry, School of Medicine, Sapporo Medical University, S-1, W-7, Chuo-ku, Sapporo 060-8556, Japan. Tel.: +81-11-611-2111x2673; fax: +81-11-611-2236
    • ,
  • Kei Takamura

      Affiliations

    • First Department of Medicine, School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, Japan
    • ,
  • Sinji Sakaue

      Affiliations

    • First Department of Medicine, School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, Japan
    • ,
  • Jun Ishii

      Affiliations

    • Department of Internal Medicine, Hokkaido Central Hospital for Social Health Insurance, 1-8-3-18, Nakanoshima, Toyohira-ku, Sapporo, Japan
    • ,
  • Hiroshi Yokouchi

      Affiliations

    • First Department of Medicine, School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, Japan
    • ,
  • Yasuyuki Nasuhara

      Affiliations

    • First Department of Medicine, School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, Japan

Received 30 June 2001; received in revised form 23 October 2001; accepted 31 October 2001.

Abstract 

To clarify the influence of blood glucose level or diabetes mellitus on serum KL-6, a mucin-like glycoprotein, concentrations, they were measured against 176 diabetic subjects, including receiving insulin (INS) group (n=54), oral antidiabetics (OAD) group (n=78), and diet and exercise (D&E) group (n=44). Serum KL-6 concentrations in the diabetic subjects were significantly greater than those in the normal healthy control subjects (643.0±32.7 U/ml, 206.5±6.1 U/ml, P<.0001, respectively), and those in the INS and OAD groups were significantly greater than those in the D&E group (708.2±66.9, 691.7±51.9, and 476.6±34.9 U/ml, P<.05, P<.05, respectively). Serum KL-6 concentrations did not correlate with urine KL-6 concentrations (n=73, r=−.044, P=.74). Immunohistochemical staining of the diabetic kidneys with a monoclonal antibody to KL-6 antigen showed positive immunoreactivity on Henle's loop, renal tubules, and epithelial cells in Bowman's space of sclerosing glomerulus. In conclusion, diabetes mellitus or complications of diabetes mellitus resulted in serum KL-6 elevation regardless of serum glucose level, but serum KL-6 concentrations were not influenced despite control of diabetes mellitus.

Keywords:  Immunohistochemistry, Diabetic nephropathy, CA19-9, HbA1c, Renal tubules, Henle's loop

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PII: S1056-8727(01)00220-3

Journal of Diabetes and Its Complications
Volume 16, Issue 5 , Pages 352-358, September 2002

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